Eniksum belongs to the group of direct anticoagulants, the main active ingredient of which is sodium enoxaparin, which in its chemical composition is a low molecular weight heparin.
The drug is enoxaparin sodium in a dose of 20 mg to 100 mg.
Produced in syringes of 0.2 ml, 0.3 ml, 0.4 ml, 0.6 ml 0.8 ml, 1.0 ml. Packed in 2 syringes in the outline package and 5 such cell packs in a cardboard box.
General pharmacological properties of the drug:
The properties of decreasing blood coagulation are manifested with antithrombin III.In addition to the ability to prevent thrombosi
When prescribing for prophylactic purposes, it can be observed:
The pharmacokinetic characteristics of the drug appear in a linear relationship. With a single subcutaneous administration of the drug at a dose of 1 milligram per kilogram of patient weight, the maximum concentration in the blood is 0.49 IU / ml.
When assessing the concentration of the drug after the administration of subcutaneously, the results were obtained about 100% of its bioavailability.
The process of drug metabolism occurs in the liver. At the same time, in the process of desulphation or depolymerization, substances with a low molecular weight structure that have low biological activity are formed.
The excretion of active fragments occurs by the kidneys and amounts to no more than 10%, and the total number of all fragments does not exceed 40% of the entire administered dose of the drug.
Eniksum is used in such cases:
The main contraindications to the prescription of this medication are:
There are conditions in which there is a high likelihood of bleeding, therefore the use of Enixum in these cases should be done with extreme caution:
To date, there is no necessary data on the use of the drug for the treatment of patients with tuberculosis and in the conduct of radiation therapy.
Eniksum should be administered subcutaneously. Intramuscular use of the drug is prohibited. The injection is done lying alternately in the left and right side of the abdomen. The syringe with the medicine is ready for use, it is enough just to remove the protection from the needle.
Based on the fact that the drug is used to stop various diseases, then for each situation there is a scheme of therapy, dosages and duration of treatment:
A video clip on how to stab Kleksan, injections of Eniksum are put similarly:
With the administration of subcutaneous high doses of the drug, there is the possibility of developing hemorrhagic complications. With oral administration of this drug, absorption of the drug almost does not occur and the possibility of an overdose is unlikely.
Antidote: Protamine sulfate. With the help of this drug, the previously introduced Eniksum is neutralized. Before you enter the antidote you need to make sure the correct ratio of risk and benefit due to the possible development of anaphylactic shock.
Protamine sulfate is able to inactivate Eniksum in a 1: 1 ratio, provided that sodium enoxaparin was administered no longer than 8 hours ago.
For repeated administration, the dose is calculated as 0.5 mg of the antidote per 1 mg of the injected drug.
If enoxaparin sodium was administered 12 hours earlier than a decision was made to administer an antidote, the administration of protamine sulfate is no longer appropriate.
During the use of this drug, the following complications may develop:
To date, there is insufficient evidence of the possibility of developing teratogenic or fetotoxic properties of the drug during its use in pregnancy, for this reason, the appointment of Enixum in this period is not recommended. Exception are cases where the benefits for women are much higher than the risk for the future of the child.
This medication is not used during pregnancy in women who have prosthetic heart valves. If the doctor decided to prescribe enoxaparin sodium during lactation, then breastfeeding should be temporarily stopped.
Due to the lack of research on the safety of the drug in childhood, its use for children under 18 years is prohibited.
If the patient has no abnormalities in the functioning of the kidneys, then the elderly patients do not need to reduce the dose of the drug.
If you have a history of severe dysfunction in the kidneys, you need to reduce the dose of the drug and conduct a study of the clearance of creatinine.
When appointing Eniksum, patients with liver diseases should be cautious because of the lack of data on the effect of the drug on a person during this period.
Precautions should be observed when using the drug to treat patients who have the following medical history:
During drug treatment it is necessary to refrain from driving a car or working with other mechanisms, because during clinical studies it was revealed that enaproxen sodium provokes headache, dizziness, drowsiness.
When using Eniksum, it is worth paying attention to the following possible drug interactions:
It will be useful to study the opinions of doctors and patients who have received or are taking Enixum at the moment.
I use Eniksum for a long time in my medical practice. To date, to treat blockage of deep veins of the thrombi, no better remedy has been found.
Phlebologist, experience of 19 years
Since I have been working in a cardiology clinic for 20 years, I know personally about preparations containing enoxaparin sodium. It should be noted that Eniksum is no different from its more famous competitors, its main difference is a more affordable price.
Cardiologist, 20 years of experience
Not so long ago the grandmother got to the hospital with unstable angina. The doctor examined her and prescribed Eniksum in combination with Aspirin in a dose of 325 mg. It took only 4 days and Granny became much easier, and after two weeks the doctor safely wrote her home.
Alina Nikolaevna, 38
During pregnancy, there was an urgent need to use Clexane. Since the drug is quite expensive, I asked for advice on something cheaper. The doctor appointed Eniksum. I chopped it out at the instruction and gave birth to my son on time.
The preparation does not require special storage conditions, it is sufficient not to exceed the temperature of 25 degrees Celsius and not to freeze syringes with the drug.
Shelf life 2 years from the date of manufacture. After the end of this time, use the drug is prohibited. Leave from pharmacies occurs only upon presentation of a prescription from a doctor.
The price of the drug depends on the amount of the main active substance, and is at the level of 1500-3200 rubles per package, and the following analogues of Eniksum can be purchased at the pharmacy:
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