Nadroparin calcium( trade name Frakssiparin) is often used to treat various thrombotic diseases, as well as the prevention of disorders associated with cardiac activity. Because this medicine is strong, its use is only possible according to the doctor's prescription.
The drug refers to drugs with an anticoagulant effect. This tool prevents the appearance of blood clots, so it is often used to treat and prevent thrombosis of superficial and deep veins.
Also, the drug is actively used for the therapy of other dangerous vascular disorders.
A drug is produced in the form of a solution whose structureColorless or has a light yellow color. The solution is placed in syringes. The drug is intended for injections under the skin.
Syringes with solution are placed in blisters. One blister can contain one, two or five syringes, which are placed in packs of cardboard.
Frakssiparin consists of the following components:
Fraxyparin is part of the anticoagulant group with antithrombotic effect. Nadroparin calcium is low molecular weight heparin, which is obtained by depolymerization from conventional heparin. If we consider this substance from the chemical side, it is glycosoaminoglycan, whose molecular weight is 4300 daltons.
This component has increased tropicity to the blood protein antithrombin 3, which as a result leads to a decrease in factor Xa. This condition causes the severity of the antithrombotic effect of the supraparin.
Other principles of increasing antithrombotic activity consist of stimulation of the tissue factor inhibitor, enhancement of fibrinolysis due to direct release of the tissue plasma plasmogen activator from endothelial cells, and also from the modification of hemorheological data - decrease in the level of viscosity of the blood structure, increase in the number of platelets, change in the granulocyte membrane.
Compared to heparin, the unfractionated type has the lowest effect on platelet activity, on the form of aggregation, and on the state of primary homeostasis.
During therapy with high activity, an increase in APTT by 1.4 times the standard can be observed. If it is used in preventive doses, then there is no strong decrease in APTT.
During the administration of the drug by subcutaneous injection, the maximum concentration in the blood is reached within 4-5 hours. Absorption of the drug occurs up to 88%.During intravenous administration, the highest concentration is observed after 10 minutes.
The elimination half-life is approximately 2 hours. Metabolization of the drug is predominantly observed in the liver by desulfated methods or by depolymerization.
be used Fraksiparin is intended for use in the following diseases:
Fraxyparin should not be used in the following conditions:
The solution is injected under the skin. When administered, the patient must lie down. The drug should be injected under the skin into the anterolateral or posterolateral abdomen. The drug is injected into each side in turn - first to the right, then to the left. You can also enter into the thigh.
The needle is inserted under the skin in a perpendicular position, but not at an angle. Before the introduction, the skin should be caught in a small crease. It is formed in the gap between the thumb and forefinger. Place the folds to be held throughout the entire injection of the drug. After the injection, the area where the medication was administered should not be ground.
Features of the use of Nadroparin depending on the purpose:
The video shows how to individually prick a Kleksana prick, the injection of Fraksiparin is done similarly:
. According to animal experiments, there are limited data that the constituent components of Fraxiparin penetrate the placenta to the baby,pregnancy time is not recommended, but in practice it is applied.
Sometimes there are exceptions when the benefit for the mother will exceed the risk for the child.
During breastfeeding, the use of the drug is not recommended, since the constituent components can be included in the milk composition.
The following side effects may occur during application of the drug:
Opinion of professional doctors and feedback from ordinary people about the drug Fraksiparin.
Frakssiparin is an effective tool for the prevention and treatment of various thrombotic diseases. This drug helps with almost the first application, it is due to its properties. The active component quickly binds to the plasma protein of the blood and as a result creates an antithrombotic effect.
In the process of treatment, blood clots, blood clots quickly liquefy. The drug reduces the viscosity of blood and increases the permeability of platelet membranes. But during the application it is necessary to monitor the blood condition, sometimes bleeding may occur.
I often prescribe to my patients Nadroparin for the prevention and treatment of various thrombotic pathologies. This drug helps to eliminate thrombosis, treats thromboembolism in severe form.
In addition, in fact, Fraksiparin can be used during pregnancy, it has been shown to have a negative effect on the mother and the baby, although the instructions say otherwise.
During the introduction, the drug quickly penetrates the blood, relieves inflammation, pain and eliminates all the unpleasant consequences of the disease. But do not forget about side effects, so during the use of the drug you must always monitor the condition of your body.
Before I became pregnant, I underwent a test on which it turned out that I had too much blood, as the doctor explained to me, the thick blood can cause thrombus formation. And thrombi during pregnancy pose a danger to the mother and child.
He prescribed me the drug Fraksiparin. At first, it seemed to me uncomfortable to do injections in the stomach, but over time I got used to it. The first time at the injection site formed hematomas, but then they passed. I pierced the drug for 2 weeks, then the tests became good.
Love, 27 years old
Because I have congenital thromboembolism, bearing a child for me is a test. This disease for the last 7 years has become for me a barrier to the birth of the long-awaited child with my husband. After I became pregnant, I immediately went to the doctor, he prescribed me to do Fraksiparin injections throughout the period. This drug is designed to dilute blood and prevent the formation of blood clots and clots. I immediately agreed. Did injections herself.
The drug does not have a harmful effect on the child. I calmly left the entire pregnancy and gave birth to a healthy baby!
Svetlana, 32 years
The price of the drug is quite high on average for a package with 10 syringes 0.3 is from 2200 and comes to 4020 rubles, per Fraksiparin package No. 10 0.6 ml - from 3400 to 5000 rubles, also available to purchase the following medicinal analogs:
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