Peculiarities of the application of anticoagulant of indirect action of Phenilin

Occlusion of veins, thrombophlebitis, inflammation, heaviness, pain in the lower extremities are all unpleasant problems that occur during thrombosis, varicose veins and other vein diseases.

It is necessary to eliminate these diseases at the time, otherwise there may be much more serious consequences. One of the effective drugs that is used to treat various diseases of the veins of Phenylin. It has long established itself as an effective treatment for the cure of veins, inflammation and thrombosis.

This is a synthetic type product that prevents excessive blood clotting. The instructions indicate that this is an anticoagulant of indirect action. The main component of the drug is phenindione.

It is due to it reduces coagulability of blood, blood clots dissolve, inflammation, heaviness and other unpleasant sensations in the legs pass.


  • Composition and Form of Release

    • Composition and Form of Release
    • Pharmaceutical Drugs
    • Indications for Use
    • When it is not necessary to prescribe the
    • tool Instruction for use
      • How to take with thrombosis and thrombophlebitis
      • How to take during thromboembolic complications
      • How to take with acute thrombosis
    • Side effects
    • Interaction withother drugs
    • Practical experience of using
    • Cost of preparation

Composition and form of release

In 1 tablet of the drug containsThe following components:

  • main component - fenindione 0,03 grams;
  • additional components - milk sugar, starch powder, talc, citric acid.

Tablets are white, sometimes a creamy shade. The form of the tablets is cylindrical.

Available in cardboard packages with blisters and glass jars.

Formula for fenindione

Pharmaceutical medicines

Drug Phenylin is part of a group of anticoagulants that have an indirect effect( agents that exert an inhibitory effect on blood coagulation).

Active ingredient - phenindione causes hypoprothrombinemia, which is associated with problems in the formation of prothrombin in the liver.

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Also leads to a decrease in the formation of VII, IX, X coagulation factors, a decrease in the level of plasma tolerance to heparin, the presence of lipid components in the blood composition and the enhancement of the permeability properties of the vessel walls.

The action of the drug begins in 8-10 hours and reaches its maximum level of concentration 24-30 hours after taking the drug.

This product has a fast and full suction. The main substance of the drug passes through the barriers of the histo-hematical type and accumulates in the tissues. The process of metabolism occurs in the liver. The excretion of the substance occurs through the kidneys in an unchanged form and in the form of metabolites.

Indications for use

Phenylline is recommended during high blood clotting, it interferes with blood clotting. It is often prescribed during treatment and for the prevention of thrombotic diseases. It should be understood that with thrombosis this remedy is taken for a long time.

In addition, according to the instructions, this drug must be taken for the treatment and prevention of conditions:

  • with thrombophlebitis - when there is occlusion of veins due to the inflammation of the vein walls;
  • in the event of violations of the thromboembolic nature of - clogging of the vascular walls with blood clots;
  • during myocardial infarction ;
  • for the treatment of strokes of the embolic type - clogging of the brain vessels, which causes serious problems with blood circulation in the brain;
  • for embolic lesions - clogging of vessels with foreign agents or blood clots.

This medication can also be taken during the postoperative period to prevent various complications.

When it is not necessary to prescribe

according to the instructions, the drug should not be taken in the following situations:

  • if there is an individual intolerance of the constituent components of the drug;
  • if the initial prothrombin content is less than 70%;
  • during various diseases during which there is a decreased blood clotting;
  • in cases of high vascular permeability;
  • if there are abnormalities in the functioning of the liver and kidneys;
  • during pericarditis;
  • for malignant neoplasms;
  • if there is a peptic ulcer of the stomach, duodenum and other erosive-ulcerative lesions of the gastrointestinal tract;
  • should not be taken during pregnancy and during lactation.

It is also not recommended to be treated with this drug during menstruation and in the first week after childbirth.

Instruction for use

The medicine is prescribed to be taken internally according to the following scheme:

  • on the first day of - for a day it is necessary to take from 0.12 to 0.20 grams, approximately 3-4 doses;
  • on the second day of - per day from 0,9 to 0,15 grams of 2-3 intake;
  • on the third day and subsequent days of - per day from 0.03 to 0.06 grams, depending on the level of prothrombin in the blood.

After this, depending on the patient's condition and depending on the individual dynamics of the decrease in prothrombin in the blood composition, the dosage of Phenilin is reduced to 0.01-0.02 in one dose. On average, the duration of treatment is from 2 to 3 weeks.

How to take with thrombosis and thrombophlebitis

For thrombotic and thrombophlebitic conditions, the drug should be taken at a dose of 0.003 to 0.005 grams at a time. For the day you need to take the pill 2 times.

The duration of this reception is 2 days. After that, the dosage is reduced - 0,002-0,001 grams per reception, twice a day is also taken.

It is accepted until the complete disappearance of diseases - 2-3 weeks.

How to take during thromboembolic complications

During the prophylactic treatment of complications of thromboembolic character, you should take in a dosage of 0.002 to 0.03 grams at a time, a day should be taken 2 times. Take it within 2-3 weeks.

How to take with acute thrombosis

During thrombosis in an acute form, it is necessary to take Phenylin together with Heparin. Dosages are the same as with the usual form of thrombosis. The maximum dosage intake inside: single - 0.05 grams, daily - 0.20 grams.

During treatment, blood levels of prothrombin should not be reduced below 40%.

Side effects of

The following side effects may occur during administration of the drug:

  • disruption of the digestive system - nausea, vomiting, diarrhea, and liver dysfunction, the onset of hepatitis in toxic form;
  • may be observed oppression of bone marrow hematopoiesis ;
  • problems in the work of the urinary system - kidney dysfunction ;
  • may appear myocarditis ;
  • during long reception observed micro and macrohematuria , bleeding from the oral cavity and nasopharynx, bleeding from the stomach and intestines, the occurrence of muscle hemorrhages;
  • can sometimes appear headache ;
  • allergy in the form of a rash on the skin, dermatitis, eosinophilia, there may be an increase in body temperature.

Interaction with other drugs

If taken concomitantly with ACTH, the effect of atikoagulant may be increased.

When taken together with dipyridamole, cases of increased bleeding are described. Perhaps this is due to a decrease in platelet adhesion and aggregation under the influence of dipyridamole.

When co-administered with the clofibrator, an anticoagulant effect is increased.

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During simultaneous administration with Lyotronin, Miconazole, Cimetidine, Ethyl estrinol, there is an increase in anticoagulant effects of Phenilin.

Practical experience of using

Having studied the opinions of doctors and patients who take Fenilin, it is possible to draw certain conclusions.

Preparation Phenylin is a good agent for prevention of high blood coagulability. In addition, its use during thrombosis, thrombophlebitis, thromboembolic diseases gives good results. Many of my patients after treatment with this drug note that they have become much better. But before taking the medicine Phenylin still needs to consult a doctor, he will be able to conduct a survey and appoint the right treatment.


Phenylline is a good preparation for both prevention and treatment of thrombophlebitis, thrombosis, thromboembolism. It helps with blockage of veins, vessels, relieves inflammation, and also prevents high blood coagulability.

But still you should not forget about contra-indications and side effects. Therefore, before you start taking this remedy, be sure to consult a doctor.

Vascular surgeon

I always suffered from thrombophlebitis, he just gave me no peace. What these edemas and pains cost. Than I only did not cure this illness, but always the effect was temporary.

After the examination, the doctor prescribed to take the drug Phenilin. I took it for 2 weeks according to the instructions. After treatment, I noticed good improvements. After examination, the doctor noted that my blood vessels and veins became clean, inflammation passed, and the pain disappeared.

But the disadvantage is that there are too many contraindications, therefore this remedy does not suit everyone!

Svetlana, 54 years old

When I noticed swelling in my legs and severe pain, I immediately went to the doctor. After the examination, I was found to have thrombosis and thrombophlebitis.

The doctor has prescribed to take Phenilin together with heparin. She took the drug according to the instructions for 3 weeks. Already in the second week I noticed a noticeable change - the swelling subsided, the pain became less, and the weight passed. And at the end of the reception these symptoms have completely gone and do not bother me so far. A year has passed since the treatment, and my legs are like new!

Marina, 42 years

The cost of the preparation

The cost of packing with the number of tablets of 20 pieces is about 75-80 rubles, the cost of packing No. 10 is from 40 to 50 rubles, the price for Fenilin packing with the number of 30 tablets is from 110 to 130 rubles.

Analogues of the preparation are available:

  • Atrombon;
  • Geduline;
  • Danilon;
  • Dindivan;
  • Thrombolyt;
  • Thrombosol;
  • Thrombofen;
  • Phenylindanedione;
  • Fenindion.
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  • Mar 14, 2018
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