Use of drugs based on rutozide in the pathology of veins

A huge number of people in the world suffer from vein diseases on the lower limbs.

If to this number to add those who suffer from the defeat of blood vessels in other parts of the human body, then there will be a countless number of patients.

Each of them faces the need to choose a drug for treatment.

Since the middle of the last century in the fight against vascular diseases patients are helped by Rutozid.

Contents

  • General information about the substance and its pharmacies
  • Application features Routine
    • To whom is assigned
    • Dosage and drug interaction
    • Special instructions
  • Application of VORORUTON
    • Indications
    • Dosage regimen
    • Application features and drug interaction
    • Practical application experience - this will be useful
    • Forms and analogues in the pharmaceutical market

General information on the substance and its pharmacological properties

Rutoside - racesbased on quercetin, obtained from fragrant rue, buckwheat and citrus f

ruits by chemical hydrolysis. Affects small vessels, reduces their permeability and fragility, facilitates the movement of blood through altered veins. Has a protective effect on the affected vessels.

Pharmacological properties directly depend on the time and method of taking the drug. When ingestion with normal functioning of the intestine, the maximum concentration in the blood is determined after 3 hours.

However, when taken after a plentiful meal or when there is a violation of absorption, the drug accumulates in the blood to the maximum values ​​within 8 to 9 hours. The minimum time to achieve the maximum action of the drug is 1 hour. When used externally, it accumulates in deep layers of the skin after 30 minutes.

Formula of Rutoside

The drug is excreted by the kidneys and bile either in unchanged form( about 40 percent), or in the form of various secondary compounds( 60 percent).

The half-life of the drug varies widely and depends on the specific features of the accumulation of the maximum concentration and mode of administration.

In young people with rapid accumulation in the blood, half of the concentration decreases in 10-12 hours. Taking into account the age and the late reaching of the maximum of blood saturation, it is deduced in half for 22 to 24 hours. The maximum possible half-life is 25 hours.

The main clinical effects when taking medication are presented below:

  • reduces edema of perennial cellulose;
  • reduces pain in the lower limbs;
  • improves the external pattern of veins on the skin;
  • removes the paresthetic sensations: "crawling crawling," numbness;
  • for external use softens, moisturizes and cools the skin.

The drug is a part of not only drugs used in the pathology of the vascular system, but also drugs for the treatment of respiratory infections.

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For direct use in patients with vascular pathology of the lower extremities is used in the following medicines:

  • Routin;
  • Venoruton.

Features of application Routine

Routine in the composition contains only rutozid in an amount of 20 mg. Produced in tablets. The drug is an angioprotector and replenishes the lack of vitamin R. The basis of the action is the effect on the vascular wall by increasing the permeability of the vessel and strengthening its wall.

When ingested, absorbed well. The availability of the drug is not more than 20 percent, with food being slightly reduced.

Creates effective concentrations in all blood vessels of the body. The maximum effect develops 3 to 4 hours after ingestion, lasts up to 6 hours. The medicine is excreted by the kidneys and bile in unchanged form and metabolized state. In the body does not cumulate. A repeated dose of toxic effects does not have.

Who is assigned

It is indicated for the following diseases:

  1. Hemorrhoids .In complex therapy, the processes of regeneration of damaged vessels of the rectum will accelerate, reduce pain and swelling.
  2. Trophic disorders of the extremities .It is able to accelerate the healing of eroded surfaces of the skin in chronic venous insufficiency.
  3. Capillarotoxicosis and hemorrhagic diathesis as a means to improve the permeability of small vessels.
  4. Vitamin P hypovitaminosis and auxiliary therapy for infectious diseases .

Monotherapy with the drug is ineffective. It is used only together with other medicines, strengthening their influence on the vessels and speeding up the healing process. The only contraindication is intolerance of the drug itself.

Dosages and drug interaction

Regardless of the degree of vascular changes, it is prescribed to an adult at a dose of 40 mg( 2 tablets) 4 times a day. Children under 15 years of age the dose is reduced. The drug is prescribed for 20 mg( 1 tablet) 3 times a day.

The drug is not used in children under 2 years due to the fact that it does not have other forms of release, except for tablets.

Special instructions

Side effects are rare and are reduced to digestive disorders in the form of small mild epigastric pain after taking the medication, sometimes nausea. Rarely, allergic reactions are easy in the form of rashes and mild headaches.

Overdose of the drug is not described. Cases of accidental or deliberate use of the drug in large doses are not recorded.

If the liver and kidney function is not corrected, dose adjustment is not required. Allowed during pregnancy, in the first trimester only under medical supervision.

Allowed to children without age restriction, the limiting factor is the form of release. The effects of the drug are dramatically enhanced by the combined use of ascorbic acid.

When using the drug, there is a moderate positive dynamics of the disease. Significantly improves the effect of drugs used together.

The use of only rutozide is permissible with a lack of vitamin P, in other cases the mandatory appointment of a comprehensive treatment.

Produced in the form of tablets of 20 mg. Produced by Russian companies. The cost of packing of 10 tablets is not more than 30 rubles.
Storage conditions are standard, protect from the effects of sunlight. It is valid for 2 years from the date of issue. Vacation from pharmacies is over-the-counter.

Venorutone application

Venoruton is a mono drug. Contains ethylated rutozides. Has several release forms:

  1. gel for external use. One gram of gel contains 20 mg of rutozide.
  2. Capsules .Contain 300 mg of rutozide.
  3. Tablets effervescent. Contain 1 gram of rutozide.

Refers to angioprotectors. It acts on all small vessels, both arterial and venous. Improves the rheology of blood by affecting the structure of red blood cells, stabilizes the endothelial cells of blood vessels. The clinical effects of taking the drug are as follows:

  • reduces edema of the affected parts of the lower limbs;
  • relieves pain and inflammation, both in the extremities and in the rectum;
  • reduces the severity of trophic disorders on the skin, accelerates the healing of ulcers;
  • promotes cessation of bleeding from the rectum;
  • has an indirect anticonvulsant effect on the lower limbs;
  • topical application has a calming effect on the affected vessels.

The maximum availability of the drug for internal use is not more than 15 percent. Nevertheless, this is sufficient to create the necessary therapeutic concentration in the vascular wall.

The maximum effect varies widely - at least 1 hour, a maximum of 9 hours. It is stored in the blood after a single dose of up to 5 days. However, effective action lasts a minimum of 10 hours, a maximum of 25 hours.

It depends on the characteristics of metabolism in different people. It is isolated in its pure form or in the form of glucuronidated metabolites mainly with bile and further through the intestine, not more than 10 percent with the kidneys.

The gel appears in therapeutic concentrations in the skin after rubbing after 30 minutes, the maximum effect after 3 hours. Absorbed into the blood and excreted in the same manner as the oral forms.

Indications for use

The main indications for the use of Venoroon are the following:

  1. Chronic insufficiency of the veins of the lower extremities .The degree of damage does not matter. Any symptoms of venous disorders the drug is able to minimize.
  2. Consequences of transferred thrombophlebitis .All residual phenomena in the form of pain, paresthesias and local circulatory disorders. The degree of severity and prescription of the process does not matter.
  3. Trophic disorders on the lower limbs of the .In advanced cases of venous insufficiency, severe trophic disorders occur, manifested by changes in the appearance of the skin of the shins and feet. Venoruton helps to eliminate these disorders and normalize microcirculation, which leads to the restoration of skin properties in the affected areas.
  4. Chronic venous ulcers .In the most severe disorders of microcirculation, ulcers occur. Improving blood flow through the vessels, blood circulation in the affected areas increases, and the ulcers heal.
  5. Hemorrhoids .All the symptoms of hemorrhoids are removed with the help of the drug.
  6. Diseases of the veins and hemorrhoids during pregnancy from the 2nd trimester of .Pregnancy is not a deterrent to prescribing the drug. Any manifestations of venous disorders can be corrected with the help of the drug.
  7. Diabetic and atherosclerotic lesions of the retina vessels .

The only contraindication is the intolerance of Venorutone or its component of Rutozide. Conditional contraindication is the first trimester of pregnancy.

Dosing regimen

Capsules and tablets are taken orally. The gel is used externally. For chronic venous disorders, the dose of the drug is 900 mg in three divided doses, if capsules are used.

Tablets are taken one at a day in a dose of 1000 mg. The course of treatment is at least 2 weeks. The average duration of treatment is a month. To achieve a stable effect, the courses should be conducted at least 2 times a year.

In the presence of lymphostasis and after surgical treatment of varicose veins, the drug is prescribed in a dose of 10 capsules per day. Three 300 mg capsules in the morning, three at lunch and four at night. Tablets are also prescribed in a high dose of 3000 mg in three divided doses. The duration of therapy with these variants of vascular pathology is at least 6 months.

For the treatment of manifestations of hemorrhoids, the maximum dose in capsules is 900 mg in three divided doses, in 1000 mg tablets in a single dose. Sometimes enough and two capsules per day to achieve the effect. Course duration is not less than 4 weeks.

The gel is used externally for pain and edema of the lower extremities against a background of venous insufficiency. It is also possible to use bruises and bruises not associated with lesions of the veins. The gel is rubbed into the skin with gentle movements twice a day.

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To enhance the effect, the gel can be used in conjunction with compression linen.

Features of application and drug interaction

Rutoside - the main component of Venorutone has good tolerability. But with the use of high doses of the drug, dyspeptic abnormalities can occur in the form of nausea, epigastric pain after taking the medication, heartburn.

These phenomena easily pass with a change in the dose of the drug or when taking the medicine strictly after a full meal. There may be headaches, which sometimes require correction by analgesics. Rarely, a rapid redness of the face is possible by improving the microcirculation in this area. The gel can cause skin allergic reactions.

In most cases, all undesirable phenomena when taking the drug are fast-passing, and withdrawal of treatment is not required. In case of protracted reactions to the drug, especially allergic disorders, it is necessary to cancel treatment.

The drug is compatible with alcohol. If there is a violation of the liver and kidney function, the dose should not be corrected, since these organs are involved in the metabolic processes of the drug mediated.

The drug is compatible with all known drugs that are acceptable for the treatment of veins. The effect of the drug is potentiated together with other agents, especially the action of ascorbic acid, taken together with Rutozid.

The substance is recommended for use in pregnancy, as is safe for the fetus in the second and third trimester. Studies of the effect of rutozide on the fetus in the first trimester were not carried out on a human.

Therefore, the manufacturer's recommendation limits the use of Venorutone in the first trimester. Nevertheless, no adverse teratogenic effects were obtained in animal experiments in superdoses.

According to the individual decision of the doctor, the drug can be used in the first trimester, if the benefit for the mother is higher than the risk for the fetus. Lactation is not a contraindication to the use of the medicine, since the substance can not harm the child.

There are no restrictions on taking medication by children. However, the form of release( capsules and effervescent tablets) is a restriction for the treatment of children under 6 years, due to the impossibility of dose adjustment. There are no restrictions for the gel.

Practical application experience - it will be useful

If you analyze the reviews of doctors and patients taking Venoruton, then the majority is positive. The drug effectively fights with venous insufficiency, there are swelling and heaviness in the legs.

Some people are concerned about the high price of the drug and the relatively weak analgesic effect. Nevertheless, it is necessary with a certain degree of skepticism to approach any feedback about the medicine found on the network.

It is not known what kind of disease was treated with the drug, as there is no medical card, which initial manifestations of the disease were objectively, and what happened in reality after the treatment. In addition, you can never be sure that the feedback is real.

Based on the experience of the drug, it should be noted its good effectiveness in the initial stages of the disease. Manifestations associated with swelling and heaviness in the legs are well corrected by the medicine.

However, monotherapy, especially gel, does not always bring the expected results. It is better to use the medication together with other venotonics.

In addition, individual recommendations on the use of 10 tablets per day for a long time, significantly reduces the compliance of patients, as the market has more affordable drugs that can be taken in a smaller dose and at a lower multiplicity.

Forms and analogues in the pharmaceutical market

The preparation has the following forms of release.

  • capsules for 300 mg of 20 or 50 pieces per package;
  • tablets effervescent for 1 gram of 15 pieces per package;
  • gel 2% concentration in a metal tube of 40 and 100 grams.

The average cost of capsules is about 800 rubles, the tablets are about 1000 rubles, the gel is about 400 rubles. The manufacturer is a Swiss company.
Shelf life 3 years. Keep in a dark place. From pharmacies is dispensed without a prescription.

The Russian market has a sufficient number of analogs with comparable effect and a competing price. Some of them are presented below:

  • Anavenol .Available in the Czech Republic;
  • Troxsevenol .Produced in Russia;
  • Troxerutin .Available in the Czech Republic and Russia;
  • Troxevasin .Manufacturer - Iceland.

Thus, rutozide trihydrate can be very safely and effectively used in venous pathology. Nevertheless, the drug has drawbacks and inconveniences in use. To resolve the issue of the advisability of treatment with rutozide, you should consult a phlebologist.

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  • Mar 19, 2018
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