Fondaparinux sodium( trade name Arikstra) is a medical preparation in the form of a clear, colorless solution. It is an anticoagulant of direct action and a selective factor Xa inhibitor.
This medication is available as a solution for subcutaneous administration. It is released in syringes, each containing 5 mg of sodium prinoprino and additional components:
Aricstra is a pentasaccharide that is obtainedsynthetically. It is able to bind selectively to antithrombin III, thus catalyzing the inactivation of the factor Xa of the homeostasis system.
Due to the inactivation, the thrombus fo
Fondaparinux has no effect on platelets and does not cause various cross-reactions. The therapeutic dose of the drug does not change the results of such coagulation tests, such as APTT, ABC and MNO.In rare cases, when taking an excessive dose of the drug( more than 2.5 mg), the APTT is lengthened.
After subcutaneous inoculation, the drug is completely absorbed from the injection site. The maximum saturation of the drug in the blood plasma is observed two hours after its administration.
The elimination half-life of the drug is twenty-five minutes after the inoculation. Most of the drug is localized in the blood and only a small amount is in the extravenous fluid.
The active ingredient of the drug binds to the AT III protein by 94%.With other plasma proteins, Fondaparinux binds in a small amount.
In vivo conditions, the metabolism of the drug has not been studied, since during normal operation of the kidneys, the medication is excreted in an unconverted form along with the urine.
In a healthy body, about 75% of the drug is excreted by the kidneys for 72 hours.
The antithrombotic activity of the drug is the consequence of selective inhibition of factor Xa. The mechanism of action of the drug consists in partial binding to the protein AT III, thereby increasing the ability to neutralize factor Xa.
As a result of neutralization, thrombus formation and thrombin are inhibited. The active ingredient does not inactivate thrombin and does not affect platelets.
Arikstru is used in the following cases:
The drug is contraindicated in the following cases:
With special care, the drug is prescribed for the following diseases and conditions:
The use of the medication should only be carried out under the strict supervision of a physician. The drug is used by subcutaneous or intravenous inoculation. Places for subcutaneous administration are the left and right anterolateral surface of the facial abdominal wall.
In case of intravenous inoculation, the drug essence is dialed into a catheter or into a container with sodium chloride( 0.9%), in which it is necessary to first dilute the drug.
After the injection, the catheter is washed with a large amount of saline.
In case of using mini-containers, the infusion is carried out for 1-2 minutes.
The dosages of the drug depend on the therapeutic purposes:
How to get a shot in the stomach:
An overdose of a medicine can cause bleeding. In this case, it is necessary to cancel the administration of the drug. To stop bleeding surgical hemostasis, plasmapheresis and transfusion of fresh blood plasma are used.
Possible side effect:
During the use of the drug in order to prevent complications after surgery, it is necessary to adhere exactly to the time during which the inoculation of the initial dose of the drug occurs( after six hours after the operation) .
In case of impaired renal function, medication is prescribed with caution, since there is a possibility of hemorrhage development. The same applies to the use of the drug in severe destruction of liver function.
With regard to the use of the drug in childhood, the administration of 0.1 mg of the drug per kg of body weight is based on the same exposure as in adults with the treatment of deep vein thrombosis.
Arikstra is not prescribed during childbearing and during lactation.
Clinical studies have shown that the combined use of fondaparinux sodium with antiplatelet agents, oral anticoagulants and cardiac glycosides has no effect on its pharmacodynamics and pharmacokinetics.
Arikstru is not recommended to be mixed with other medications, as there is no data on their compatibility.
Reviews of practicing doctors, as well as their patients who took the drug Arikstra.
Very effective drug, but with improper application it can cause bleeding. I appoint it only after a careful examination of patients and strictly follow the process of injection.
Arikstra really has a positive effect, but the only drawback is that it has side effects. I do not recommend using it myself without prescribing and monitoring the doctor.
I was pricked with this drug, because I was diagnosed with acute thrombosis. There were no side effects, but the state of health was not very good. I was administered 2.5 mg of the drug once a day.
My husband was stabbed with this medicine four times( he got into an accident and did several operations to him).But half a year has already passed and he is constantly headache and there are dizziness.
I consulted with a neurologist, I thought it might be such a long-term side effect, but he said that this can not be. Therefore, we do not even know what it could be.
It can be seen from the experience of using the drug that in most cases it has the necessary effect, but many side effects may appear.
Arikstra is produced in the form of a solution and dispensed in syringes, the average price of the medication is 5000-6000 rubles.
The drug should be stored at a temperature of no more than 25 degrees in a place inaccessible to children.
Freezing solution is not recommended. The drug is dispensed only by prescription.
Analogues of Arikstra medication:
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