Urokinase( Urokinase) belongs to the group of fibrinolytic drugs.
The drug is available as a lyophilizate for infusion administration.
Represents a sintered mass or white powder.
Each vial of the preparation contains the active substance "urokinase" in four possible dosages:
The medicamentis a direct activator of fibrinolysin, which is converted from glu- and lysprofibrinolysin byX activation.
Fibrinolysin, in turn, contributes to the destruction of fibrin, which dissolves the thrombus. The degradation products of fibrinogen, which are formed much later, show a direct inotropic effe
Urokinase is administered exclusively intravenously or by intra-arterial droplet. The process of transformation of the main active substance occurs in the liver, and inactive metabolites are excreted with bile and urine.
The half-life of the drug is no more than 16 minutes, but the effect of its administration is maintained up to 6 hours.
Use of the drug Urokinase is possible in the presence of a patient:
In the course of clinical trials, it was possible to identify such conditions and diseases in which the use of the drug is prohibited:
The following Urokinase administration is possible:
Use the preparation immediately after dissolution in physiological saline( 0.9% NaCl).In parallel with the administration of the drug, intravenous infusion of Heparin is carried out and the activated partial thromboplastin time( APTT) is monitored.
Scheme and dosages depending on the patient's condition:
The only symptom of an overdose is profuse bleeding. The main method of stopping this state is to perform compression.
If this method manifests itself as ineffective, then the use of Urokinase stops, and it is replaced with hemostatics.
Aprotinin is one of the drugs used to stop bleeding. It is administered at a dose of 500,000 to 1 million KIE / h, followed by a decrease to 50-100 thousand KIE / h.
All measures to eliminate overdose are in the presence of transfusiologists and hemostasists.
On the frequency of occurrence it is possible to single out such side effects after the use of the medicine:
Drug interaction Urokinase with drugs:
Clinical studies on the effects of Urokinase on the fetus during pregnancy and lactation have not been carried out, so there is not enough evidence on the safety of the use of the drug during this period.
To date, there is no precise information on the isolation of the active substance with breast milk during lactation, so when prescribing a therapy, breastfeeding should be discarded.
During the course of treatment, it is necessary to refuse the introduction of drugs intramuscularly and from the use of catheters with rigid cannulas.
Elderly patients are at increased risk of intracranial hemorrhage. It follows that the prescription of the preparation is necessary after assessing the risk and benefit for this category of people.
In the presence of a history of abnormalities in the liver and kidneys, a reduction in the doses of the drug is recommended. With such diseases, the level of fibrinogen should not fall below the level of 100 mg / dl.
Because clinical studies of the drug among children have not been carried out in full, it is forbidden to use Urokinase up to 18 years for patients under 18 years of age.
The effect of this drug on the ability to drive vehicles and other mechanisms is negligible.
Use this medication with extreme caution when:
On the use of the drug Urokinase from the words of doctors, as well as their patients.
Today, I treat patients with vein thrombosis more than successfully. The drug has proved itself from the positive side. Adverse reactions occur rarely and are amenable to cupping.
Phlebologist, seniority 23 years
I have been familiar with the drug for several years and actively use it to treat coronary thrombosis. It is worth noting the effectiveness of this medication in this condition. Since often I deal with elderly patients, the drug has proved to be quite safe.
Cardiologist, experience 17 years
My mother has had problems with veins for a long time. What we did not do, but we could not achieve a positive result. Our attending physician advised to go to the hospital and undergo a course of treatment with Urokinase. Of course, at first the therapy did not take much time, but improvements are already visible. I hope that this time everything will be fine.
Last month, my grandfather was hospitalized with acute myocardial infarction. We bought all the necessary drugs, including Urokinaza Medak and to date my beloved grandfather is already at home.
Depending on the dosage of the main drug component, the average price for Urokinase is between 790 and 11500 rubles.
The drug does not require special storage conditions. It is enough to keep the temperature not higher than 25 degrees Celsius and store the drug in a dark place away from children.
The drug is dispensed from pharmacies solely on prescription.
In the pharmacy, analogues are also available for sale, which, if necessary, can replace Urokinase:
There are also medicines that have the same effect:
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