The use of Argosulfan ointment for trophic ulcers

Argosulfan is a medicinal product for external use, with a pronounced antibacterial effect.

Medication belongs to the category of sulfonamides, the main active component in the composition of Argosulfan is silver sulfatiazole.

The drug has a pronounced regenerative and wound healing properties, and therefore found wide application in the field of treatment of trophic ulcers and other wounds.

Table of contents


  • Pharmacological action
  • Pharmacokinetics of medicament
  • Composition and means of formulation
  • Mechanism of action
  • Scope
  • Contraindications and limitations for prescribing
  • Features of application
  • Overdose and side effects
  • Special instructions
  • From the practical experience of people
  • Professionals have their opinion
  • Forms of releaseand the price

Pharmacological action

Argosulfan has a pronounced antibacterial effect, so it is recommendedto the use for the treatment of trophic, purulent and infected wounds. Also,

the drug is used in the treatment of thermal burns, reducing the likelihood of subsequent infection of the wound surface.

The main active ingredient in the medicament is silver sulfatiazole, which is an antimicrobial, bacterostatic agent, which is characterized by increased activity against many Gram-positive and Gram-negative bacteria.

The drug also has an analgesic effect, helping to reduce the severity of the pain syndrome that accompanies inflammation, and the presence of silver ions in the drug, several times increases the bactericidal effect of the drug.

Due to the fact that the drug is intended for external use, it does not have a toxic effect on the human body.

Pharmacokinetics of medicament

With the local use of Argosulfan for a long period of time, a stable high level of active substances remains in the application area due to the fact that silver sulfatiazole is characterized by minimal dissolution indices.

A small amount of drug enters the bloodstream, which is then acetylated in the liver, after which it is excreted in the urine in the form of inactive metabolites. It should be remembered that when applied to a large area of ​​damage, the absorption of the drug is significantly increased.

Composition and form of release

Argosulfan is available in a pharmacological form of a cream intended for external use having a 2% concentration of the active ingredient.

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The cream has a thick, thick consistency, white, gray or pink. The preparation is packed in an aluminum tube and cardboard package. The tube contains 15 or 40 mg of cream.

The composition of the ointment is represented by the main active substance sulfatiazol silver, as well as additional components, which include cetostearyl alcohol, paraffin liquid, vaseline, sodium lauryl sulfate, glycerol, potassium dihydrogen phosphate, water.

Mechanism of action

The mechanism of action of silver sulfatiazole is based on the ability of the active component to inhibit growth and the subsequent multiplication of pathogens. This occurs as follows - silver ions present in the composition of Argosulfan bind to DNA cells of pathogenic microorganisms.

This exposure provokes a disruption of the normal synthesis of dihydrophilic acid, as well as tetradihydrofolic acid, which acts as its active metabolite. Ultimately, the process of synthesizing purines and pyrimidines in the pathogenic cell is disrupted - and the pathogenic microorganism is killed.


In accordance with the instruction, Argosulfan ointment is recommended for use in the following cases:

  • various burns to skin - effective for thermal, chemical, solar, radiation, electric burns of any severity;
  • strong frostbite ;
  • any household injuries and skin damages - purulent wounds, abrasions, cuts;
  • medication is recommended for the use of in the treatment of decubitus ulcers and trophic ulcers , which often occur in patients with diabetes mellitus, chronic venous insufficiency, endarteritis;
  • is used for treatment of various skin diseases - simple contact or infected dermatitis, impetigo, microbial eczema.

Contraindications and limitations to the prescription of

The drug has the following contraindications for use:

  • is not recommended for use in cases of congenital glucose-6-phosphate dehydrogenase deficiency;
  • is not used for the treatment of premature babies, or for children under 2 months of age, in this case, Argosulfan may trigger the development of so-called "nuclear" jaundice;
  • the patient has a shock condition after voluminous burns;
  • should also be discarded from the use of the drug in case of detection of hypersensitivity to silver sulfatiazole and other components that are part of the medicament;
  • contraindication is the period of breastfeeding.

Special application of

Argosulfan is intended for external use - it can be worn on affected areas of the skin both in an open form and with the use of sterile dressings. The affected surface must be thoroughly rinsed and treated with an antiseptic, after which it should be applied with a thick layer of at least 3 mm thick.

The medicinal preparation is applied to the surface affected by a trophic ulcer no more than 3 times a day. If during the day the cream is wiped off from any area of ​​the wound, it is applied repeatedly. The entire affected area should be covered with Argosulfan. The maximum allowable daily allowance of the drug is not more than 25 mg.

In some cases, during the treatment on the surface of the wound may collect exudate - it must be carefully removed before each application of the cream. To remove accumulated exudate, it is recommended to use chlorhexidine or a solution of boric acid.

The duration of treatment is determined on an individual basis. The maximum permissible period of application of Argosulfan should not exceed 8 weeks, otherwise permanent medical monitoring is necessary.

Overdose and side effects of

To date, cases of drug overdose have not been documented.

When medicinal product is applied to a vast affected area, the drug enters the bloodstream, which can provoke the appearance of various side effects that can be expressed in the form of local allergic reactions - the appearance of itching, redness, flaking, puffiness, and other hypersensitivity reactions in the application area.

The composition of the drug is cetostearyl alcohol, which can lead to the development of contact dermatitis.

Special instructions

Simultaneous reception of alcoholic beverages and application of Argosulfan to the limb does not have any interaction. But it should be remembered that ethanol in any form can provoke side effects of the drug or strengthen existing ones.

Patients who have impaired renal and hepatic function should use the drug with extreme caution and only under strict medical supervision and with constant monitoring of the serum silver sulfatiazole level.

It is strongly recommended not to combine Argosulfan treatment with other medications for external use.

In addition, during the treatment it is necessary to refuse the intake of folic acid and its analogues, since this can significantly reduce the antibacterial effect of the drug.

The use of the drug throughout the trimester of pregnancy and breastfeeding should be done under constant medical supervision. The use of Argosulfan is allowed only in cases where the affected area of ​​the body occupies not more than 20% of the entire surface of the skin.

Ointment is allowed for use in children who have reached 2 months of age. In case the baby is younger or premature, the cream is not recommended, since it can lead to the development of infantile jaundice.

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From the practical experience of people

Reviews of people who used Argosulfan for the treatment of trophic ulcers and other diseases and problems.

I received a severe burn on my leg, accidentally touching the stove in the bath. A friend recommended Argosulfan - after only 3 weeks from the burn there was only a small speck. I think soon it will disappear.

Lily, 28 years old

My mother is very sick, does not get out of bed. Despite the fact that I devote all my time to her care, varicose veins developed and against her background trophic ulcers of the shins. Argosulfan was advised in the pharmacy. Has bought or purchased.

Now, after 2 weeks, the skin condition has improved noticeably, we will continue to use it. The instructions say that you can use cream for 2 months.

Olga, 38 years old

The child accidentally got severe burns to his legs - he poured himself a kettle with hot water. Than we only did not smear, improvements were not, the kid cried and shouted. A familiar pediatrician advised Argosulfan cream. Within a week, the son feels much better, the wounds began to lighten and tighten.

Natalia, 23 years

Result of treatment with Argosulfan

Professionals have their own opinion

I have been working as a pediatrician for many years. Every day dozens of parents are treated with a problem of wounds, suppuration or burns in children. To my patients, I recommend Argosulfan cream - it has a minimum of contraindications and is of maximum benefit.

Nadezhda Viktorovna, 48

As an endocrinologist with years of experience I can safely advise my patients Argosulfan. This preparation in the form of a cream is highly effective in the treatment of trophic ulcers in people with diabetes mellitus. The most important thing for obtaining a positive result is to follow the drug instruction exactly.

Oleg Petrovich, 52 years

Forms and price

The drug is produced in the form of cream 15 and 40 mg. The average price of Argosulfan in the pharmacy chain can range from 290 to 380 rubles.

The cream should be stored at a temperature that does not exceed 25 ° C, away from sunlight. The drug should not be stored in the refrigerator or frozen. In pharmacies, the product can be purchased without a prescription.

The structural analogues of Argosulfan include silver sulphathiazole. By pharmacological action to analogues are:

  • Sulfargin;
  • Dermasin;
  • Streptocide.
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  • Mar 01, 2018
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