How to take Clostilbegit to stimulate ovulation

Clostilbegit is a medical preparation based on synthetic non-steroid estrogen, which stimulates the process of ovulation in a woman. Initially, this medicine was created for contraception, but since 1967 it was used to induce ovulation. The drug has a number of side effects and restrictions on use, so before applying Klostilbegit, you need to go through a full medical examination and get a specialist opinion.

  • Composition
  • Ovulation stimulation
  • Scheme of admission
  • Indications for use
  • Contraindications
  • Side effects
  • For men
  • Alcohol
  • Analogues


Clostilbegit is considered a very strong preparation of the gynecological group belonging to the group of antiestrogens. Its active ingredient is clomiphene citrate. Even in a small dosage, the drug significantly enhances the secretion of gonadotropins, which is effective for stimulating ovulation in the female and suppressing androgen deficiency and oligospermia in men.

Klostilbegit is an artificially created non-steroidal estrogen similar to that produced by the female body. It occupies estrogen receptors for several weeks, in contrast to estradiol, which does this only a few hours, which explains the effectiveness of stimulation.

After administration, Klostilbegit is well adsorbed, metabolized in the liver and excreted through the intestine within a week. Thus, it indirectly stimulates ovulation in women, while activating a physiologically normal menstrual cycle.

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Ovulation stimulation

Stimulation of ovulation by hormonal drugs is performed only if the gynecologist diagnoses "no own ovulation," and the woman does not have to restore her own ovulation. This drug artificially provokes the possibility of fertilization for a certain period, for which it is possible to have time to get pregnant.

Treatment with such drugs is made only after a comprehensive examination. Particular attention is paid to finding the cause of the violation of natural ovulation, which can be, for example, in the abnormal level of thyroid hormones, adrenals, etc. In some cases, the alignment of hormonal failure resumes the correct processes in the female body, and conception can occur without stimulation.

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Scheme of reception of

There are several schemes of stimulation by Klostilbegit, the choice of which is performed by the doctor on the basis of the diagnosed diagnosis.

For patients in whom the menstrual cycle is regular, stimulation is prescribed on the 5th day of the cycle or at 3, if ovulation is early. With amenorrhea( no monthly), treatment is possible on any day of the menstrual cycle, and with anovulatory infertility( no ovulation in the cycle), everything depends on the sensitivity of the ovaries.

Stimulation Clostilbegitom according to the first scheme should be performed within 5 days of 50 mg per day with direct clinical control or laboratory testing. In this case, ovulation should begin on the 11-15th day of the cycle, but if this does not happen, then you need to go to the second scheme.

In the second course, the dose increases: from 5 days of the next cycle, 100 mg per day for 5 days. If after that the expected ovulation does not come, then the circuit is applied one more cycle.

After another failure, it is best to stop taking the drug for 3 months. After this time, treatment begins with the first scheme. If after 2 courses of treatment on both schemes the drug did not give any results, then the subsequent treatment is inappropriate and ineffective for them.

Do not exceed the dose prescribed by the treating doctor in order to achieve the desired goal. The total dose of the drug for one course should not exceed 750 mg.

If a woman has polycystic ovary, then treatment should begin with 50 mg per day, since there is a possibility of hyperstimulation.

In the absence of menstruation due to long-term use of contraceptives, you need to undergo a five-day course of treatment with Klostilbegit 50 mg per day. Usually this course gives results after the first attempt.

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Indications for use

  • Ovulation disorders.
  • Oligomenorrhea( a break between menstrual cycles for more than 40 days).
  • Secondary amenorrhea of ​​different etiology( including after the use of contraceptives).
  • Syndrome of Stein-Leventhal.
  • Oligospermia.
  • Chiari-Frommel syndrome( postpartum prolonged amenorrhea-galactorrhea syndrome).
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Read also about how the procedure of one of the simplest and most accessible kinds of assisted reproductive technologies - artificial insemination is carried out
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  • Individual intolerance of the components of the drug.
  • Suspected pregnancy.
  • Ovarian cyst.
  • Dysfunction of the liver.
  • Uterine bleeding.
  • Malignant neoplasms.
  • Primary hypofunction of the pituitary gland.
  • Visual impairment.
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Side effects of

An overdose of the drug may cause:

  • nausea and vomiting;
  • dizziness and headache;
  • depression;
  • tides;
  • vision impairment;
  • anxiety and insomnia;
  • pain in the lower abdomen;
  • increased fatigue;
  • increase in body weight.

All these symptoms pass after discontinuation of drug treatment.

In the instructions for using Clostilbegit, there are recommendations not to use it more than 5-6 times in life, as abuse can lead to early menopause, exhaustion, hyperstimulation or rupture of the ovaries, hormonal disorders, ovarian cyst, etc.
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For men

The drug is also prescribed for men with a poor spermogram( in the case of androgen deficiency or oligospermia).Treatment is carried out for 6 weeks at 50 mg 1-2 times a day with systematic monitoring of spermogram.

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Clostilbegite and alcohol are incompatible, since the therapeutic effect of the drug in the presence of alcohol in the blood practically reduces to zero. Moreover, joint application increases the likelihood of aggravation of the side effects of the drug: the degree of allergic reactions is increased, vomiting, nausea, deep depressive states are provoked, psychological depression, unfounded irritability appear.

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Alcohol-containing substances, getting together with Klostilbegit in the blood, can lead to toxic poisoning, which entails various abnormalities of the abdominal organs.

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The only analog of Clostilbedite is Klomifen.

  • Jun 02, 2018
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