The drug Wessel Duet F refers to drugs that affect the coagulation state of the body( homeostatic equilibrium of coagulation and anticoagulation systems).
The drug has a direct anticoagulant( anticoagulant) effect on the system. This effect determines the possibility of using the drug in thrombophilic conditions, a tendency to thrombosis and diseases, with a pronounced increase in the serum of procoagulant substances.
Contents of
- What are the forms of the preparation
- Features of pharmacokinetics and pharmacodynamics
- Areas of application
- When is the agent harmful?
- How to effectively use the drug?
- Side effects and overdose
- What are the advantages and disadvantages of using
- The opinion of patients and doctors
- Conditions for the release and storage of the drug
What are the forms of the drug
The active ingredient of the drug is sulodexide. It is a part of the released drug in ampoules and capsules. 
The amount of the active chemical compound is evaluated according to the LDL-lipoprotein lipase units.
Wessel Doué F in ampoules contains 2 milliliters of solution for parenteral administration( intramuscular and intravenous).600 le of sulodexide are dissolved together with sodium chloride in water for injection. Organoleptic characteristics: yellow opalescent liquid.
Capsules of the drug contain 250 LE of the active ingredient and inactive( stabilizing) components: colloidal silicon dioxide, triacylglycerides. Outwardly it is red capsules, soft, inside contain a white suspension( sometimes grayish or pink).
Peculiarities of pharmacokinetics and pharmacodynamics
The pharmacological effects realized by the preparation include:
- anticoagulant effect;
- antithrombotic activity;
- angioprotective effects;
- fibrinolytic activity;
- oppression of the proliferation of the mesangial component.
Anticoagulant effect is realized due to the affinity for the thrombin inactivating cofactor of heparin. In turn, vasoprotection is carried out as a result of restoring the normal charge of the basement membrane structures( normally the charge is negative).
Due to participation in lipolysis( activation of lipoprotein lipase), the circulation of atherogenic lipoproteins decreases, which is accompanied by an improvement in the rheological characteristics of the blood. This circumstance, together with the effect on the secretion of prostanoids, the oppression of the Praweer-Stewart factor, causes antithrombotic activity.
The pharmacokinetics of sulodexide, the main component of Wessel Douay, are listed below:
- absorption in the endothelial lining of the vessels is 90%;
- absorption occurs in the small intestine;
- the kidneys, like the liver, participate in the metabolic transformations of sulodexide;
- absence of sulfate elimination process( desulphation) favorably distinguishes Wessel Doué F from Heparin: this circumstance explains the accelerated excretion of the drug from the body, does not reduce the antimicrobotic properties;
- for 4 hours the drug undergoes a metabolic transformation and is eliminated by filtration in the renal tubules.
Area of use of
What diseases are considered indications for use of Wessel Doué F:
- Diseases of the lower extremities veins , including thrombosis of the superficial and deep veins. The effective use of
sulodexide is due to antithrombotic and anticoagulant effects. Used for the treatment and prevention of retrombosis. - Complications of external and internal hemorrhoids ( thrombosis of hemorrhoids).
- Microangiopathic complications of diabetes mellitus .This group includes retinopathy( damage to the retina of the eyes), diabetic kidney damage( nephropathy), polyneuropathy( especially ischemic forms).High lipoprotein lipase activity explains high antithrombotic efficacy.
- Infection of medium and large caliber vessels with diabetes .This group of indications includes ischemic heart disease, the syndrome of diabetic foot injury( SDS), encephalopathy of varying severity.
- Glomerulopathies with nephrotic syndrome.
- A Terosclerotic lesion of peripheral vessels of the extremities ( especially within the framework of diabetic macroangiopathy).This includes atherosclerosis of cerebral vessels with the development of encephalopathy, up to the violation of cerebral circulation( stroke).
- APS - antiphospholipid syndrome ( thrombophilic condition).
- Vasopathies after a heart muscle cardiac infarction as an alternative to acetylsalicylic acid preparations, which is especially important for gastropathies( erosion, stomach ulcers, including NSAID-associated).
When is the remedy harmful?
Contraindications to medication use include the following conditions:
- allergic reaction to the drug;
- pregnancy( concerns the first trimester);
- predisposition to hemorrhages( initial hypocoagulation background), it is dangerous to have severe bleeding;
- leukemias and other hemoblastoses;
- endocarditis.
How to effectively use the drug?
The optimal scheme of the drug presupposes a "stepwise" approach: a smooth transition from parenteral administration to the administration of capsules. Intravenously, Wessel Doué F is administered for 2-3 weeks( at the discretion of the doctor), diluting in 0,9% of sodium chloride solution( drip introduction) in 200 milliliters or injecting bolus.
It is also possible to use intramuscular means. After injections, they switch to oral administration: 1 capsule of Wessel Douche twice per day.
The course of admission is up to 3 months. It is advisable to repeat courses of treatment twice or thrice a year.
Special instructions require such situations as impaired renal function, liver, use in geriatrics and pediatrics, pregnancy and lactation.
In pediatrics, the drug is not used. In thrombotic therapy, elderly people do not have titration and dose administration. The use of the drug is undesirable in CKD of the 3rd and later stages of kidney damage.
Side effects and overdose
Among the side effects when using the drug often allergic manifestations of the type of urticaria. In the area of injection, it is possible to form a hematoma. Dyspeptic phenomena include nausea, pain syndrome in the epigastric region.
Overdose with sulodexide is possible with a one-time use of 750 leu( 3 or more tablets) inside and with the introduction of the contents of 2-3 ampoules Vessel Doue F.
Given the individual tolerability, overdose symptoms may appear when using smaller doses. It is worth paying attention to bleeding, on the appearance of urine of red color or feces of black color. In this case, taking the drug is canceled.
What are the advantages and disadvantages of using
The advantages of taking Wessel Duet are due to the pharmacokinetic characteristics, the characteristics of its action on the vascular wall and the extracellular matrix.
Let's list the advantages of this drug in comparison with other anticoagulants:
- a lot of pharmacological effects, effectively used in the treatment of hypercoagulable conditions;
- antithrombogenic action, coupled with a delayed secretion of mesangial cells, makes Wessel Doue a drug of choice with concomitant diabetic vascular lesions of different calibrations;
- is the only medication that reduces proteinuria and its toxic effects in the early stages of diabetic nephropathy;
- excretion by the kidneys advantageously positions the drug for use by patients with hepatic failure;
- more pronounced anticoagulant effect due to lack of desulphation of the drug;
- monitoring of coagulometric parameters is not required( only before starting reception).
Opinion of Patients and Physicians
Reviews patients who use Wessel Doué F in practice, as well as their physicians.
I suffer from diabetes for 7 years. Before the application of insulin, it did not work - I confine myself to metformin. A year ago in the general analysis of urine found a protein. My attending physician, an experienced endocrinologist, appointed me Wessel Douay.
First pricked in muscle, then 2 months I drank capsules. In the analysis of urine is almost pure, no protein. I drink now the drug every 3 months.
Igor, 54 years old
I take the drug courses for a year already. Have appointed or nominated in occasion of trombirovannoj wreaths in the left anticnemion. I also suffer from diabetes mellitus.
With the foot for today everything is in order. New blood clots, which we so feared with my doctor, did not arise. I will continue taking the drug further.
Katerina, 48 years old
Not for the first time I use a drug for the therapy of my patients for prophylaxis of prothromboses. In a small percentage of effective use prevent allergic reactions.
Trying to avoid them can be used while eating. The results make me happy: in comparison with heparins, including low-molecular weight, the drug has many advantages.
Igor Rakitsky, surgeon-phlebologist
I widely prescribe the drug Wessel Doue for the treatment of nephrotic level of proteinuria in diabetes. The protein in the urine returns to normal already at week 2 of use.
In practice there was a case of treatment of a patient with glomerulonephritis with concomitant diabetes. Prepart effectively controlled proteinuria.
Levon Artemovich, endocrinologist
Conditions for the release and storage of
The drug is dispensed without a doctor's prescription. Buy an ampullated form is possible in all pharmacy chains for 1700-1800 rubles for 10 ampoules of 600 le of sulodexide.
It is preferable to purchase 1-2 packs for the course of treatment. Capsules of 250 LE in the amount of 50 pieces can also be found in almost all pharmacies within the limits of 2350-2450 rubles. A full course of treatment requires the purchase of 1-3 packs of the drug.
Dosage forms are stored in an inaccessible place for children to avoid accidental use. The storage temperature should not exceed 30 ° C( not necessarily in the refrigerator).The drug is suitable for use for 5 years.
Among the analogues of Wessel Douay, you can purchase Angioflux. Produced in Italy. Russian analogs of the drug are not available.