Combined drugs that combine several active ingredients are popular and in many ways surpass the effect of mono-drugs. Ibuklin is a combination of ibuprofen and paracetamol. The first component has a non-steroidal anti-inflammatory, analgesic effect, which is supplemented by powerful antipyretic abilities. The agent has broad indications for use, but it should be treated with caution because of the possible toxic effects of non-compliance with the dose.
Will Ibuquin help with monthly pain and premenstrual syndrome, what is the cost and analogues of the drug?
drug Pharmacological action
Ibuprofen drug - means of combined action, has analgesic, antipyretic, anti-inflammatory effect. The effectiveness of ibuklin in comparison with the individual effect of each component is several times higher. The composition includes:
- ibuprofen - a substance from the group of non-steroidal anti-inflammatory drugs;
- Paracetamol is a drug related to anilids, atipyretics and analgesic.
Ibuprofen affects the enzyme level by inhibiting cyclooxygenase 1 and 2( COX-1 and 2).These substances are responsible for the production of prostaglandins, which directly initiate and potentiate the inflammatory response in tissues. Ibuprofen affects both COX-1 and COX-2, i.e.has a non-selective effect, which causes a negative effect on the mucosa of the gastrointestinal tract. Therefore, the excess of the duration and dose of the drug can lead to the formation of ulcers and bleeding, especially against the background of the already existing pathology, for example, with gastritis, even in the anamnesis.
Paracematol( in Europe, this drug is known as acetaminophen) also inhibits the effects of COX-1 and COX-2.But, unlike ibuprofen, it acts on these enzymes only in the brain tissues, and its peripheral influence is minimal. Paracetamol also directly reduces the sensitivity of the thermoregulatory center. Both these effects lead to a pronounced antipyretic ability, as well as anesthesia. But the anti-inflammatory effect is minimal.
Paracetamol rapidly penetrates into all body environments, the main metabolism occurs in the liver. With depletion of hepatocyte function can lead to cell necrosis. It is excreted mainly by the kidneys. It is noteworthy that only 1% of the ingested substance penetrates into breast milk, so it is possible to use during lactation.
Indications
Most often, ibuklin is used as an antipyretic. It is also quite effective to use it for the purpose of analgesia in various conditions: dental and menstrual pain, dislocations, sprains, bruises, etc.
Ibuqueline has proven itself to reduce sensitivity and reduce temperature in inflammatory diseases of ENT organs, SARS and others.
Look at the video about painful menstruation:
Contraindications
Despite widespread use of the drug, its use should be treated rationally, weighing all possible pros and cons. Contraindications to the drug stem from the characteristics of its metabolism and effects. The basic conditions when you should pay special attention to the possibility of receiving funds:
- Individual intolerance to any of the drugs of the NSAID group, including aspirin.
- In the presence of chronic gastritis and peptic ulcer of the stomach and duodenum in the anamnesis, as well as during Helicobacter pylori care, one should carefully observe your own sensations and do not exceed the dose and duration of administration indicated by the doctor. If it is necessary to prolong the use of drugs with this effect, it is better to give preference to selective inhibitors of COX, when the effect on the digestive tract is practically excluded.
- You should not use the medicine at the time of exacerbation of gastritis, peptic ulcer and other diseases of the gastrointestinal tract.
- Caution should be given to ibuklinu in the presence of renal or hepatic insufficiency, including chronic hepatitis. In these situations, the level of enzymes in the blood should be monitored.
- Children under three years of age are better off giving preference to other, mono drugs.
- Simultaneous use of drugs that affect the exchange of enzymes COX-1 and 2( aspirin for the prevention of vascular diseases, hormones, anticoagulants) can exacerbate the occurrence of adverse reactions from the gastrointestinal tract and blood counts.
- During pregnancy and breastfeeding, the use of ibuklin is possible. Observations did not reveal any negative, including teratogenic effect on the developing baby.
- In the presence of bronchial asthma, optic nerve diseases should also be consulted with a doctor before use.
- Caffeine is able to enhance the analgesic effect of ibuklin. Simultaneous intake of alcohol enhances the negative effect on liver cells.
- With the use of ibuklin in case of diabetes mellitus, the drug may enhance the effect of the latter.
The recommended dose of
The maximum daily dose for an adult drug is no more than six tablets, and the duration of administration is from three to five days. With this scheme, the risks of complications are minimal.
On average, 1 to 2 tablets in 2 to 3 doses per day. If you need to use in children under 12, the scheme should be chosen together with the doctor based on the clinical situation.
In the case where longer use is required, blood indications and hepatic enzyme levels should be monitored.
Can an overdose of
occur. Overdose cases are possible if the dose and duration of admission are not respected. Also, these conditions can develop with hepatic and renal failure. Main symptoms of overdose:
- Nausea, vomiting, dizziness, blurred vision, dyspepsia, pain in the stomach and intestines until bleeding develops.
- Inhibition of the production of blood cells.
- Renal failure and necrosis of the liver, toxic hepatitis.
Ibuqueline and monthly: whether it is safe to drink it
As a means to reduce the manifestation of premenstrual syndrome, ibuklin is not suitable, since it promotes fluid retention, which will only aggravate the clinical picture of .
You can also relieve pain during ovulation and on the eve of menstruation. However, caution should be exercised in the following cases:
- If the pain is atypical: more intense, accompanied by nausea or vomiting, etc.
- If suspected of an acute abdomen - appendicitis, ruptured cysts and others.
We recommend to read an article about analgesic tablets with monthly. From it you will learn about the causes of pain and how to eliminate it, medications that help to relieve the spasm.
Price and analogues of
The average cost of the drug varies from 100 to 150 rubles, depending on the region of Russia and the category of pharmacy. A medication in a smaller dose( Junior) containing 100 mg of ibuprofen and 125 paracetamol is cheaper, and the standard adult dose is 400 mg and 325 mg, respectively, more expensive. Ibuklin is a medicine manufactured by the Indian company Doctor Reddys, which has proved itself well in the pharmaceutical market.
There is also a large number of drugs with this effect. The main ones are the following:
- Ibumet and brustan( analogous hayrumat) of Belarusian and Indian production, respectively, are completely identical to ibuklinu 400 + 325.Their cost is from 100 to 150 rubles.
- The Russian edition contains 200 mg of ibuprofen and 200 mg of paracetamol. Also at an affordable price.
- Nurofen multisymptom contains 400 mg and 325 mg of active ingredients. These pills produced in the UK cost about 200 - 250 rubles.
Ibuquin is a combined drug that helps relieve pain and fight inflammation and fever. Cleverly arranged active substances make it possible to enhance the action of the drug. Ibuklin should be taken as prescribed or recommended by a doctor who, at discharge, takes into account the likelihood of complications. If the instructions are followed, the incidence of adverse reactions and overdose are minor.