Glaucoma is one of the most common eye diseases that interfere with good eyesight.
Combigan is a combined antiglaucoma preparation that is designed to reduce pressure inside the eyeball.
Due to this effect, the effectiveness of active substances is enhanced.
In this article, we will review the instructions for using the drug, how to correctly take it and whether it has contraindications or side effects.
Instructions for the use of the medicine
Next, we will review the information on the indications and the required dosage. Also, we will provide information on the form of release, as well as the composition.
These data need to be carefully examined so that in the future not to face negative consequences.
Indications
Among the indications, one can distinguish such manifestations as:
- Open form of glaucoma;
- Intraocular hypertension;
- The period before and after surgery for glaucoma.
In addition, the drug is recommended to use in the event that local beta-adrenoreceptor blockers do not have the desired effect.
Method of taking
The drug is recommended for use in the treatment of adult patients, including elderly patients.
The drug should be instilled in the eye 1 drop 2-3 times a day. The interval between meals is at least 12 hours.
The combigan can be combined with other ophthalmic medicines to reduce pressure inside the eye. If the patient uses several drugs, then you need to make a five-minute break between doses.
Composition
give information about the composition and the form in the following table:
| Product form | Eyedrops |
| vial volume | not more than 5 ml |
| Physical properties | solution sterile and transparent |
| main active ingredients | timolol maleate, brimonidine tartrate |
| Excipients | Sodium monohydrate, water, benzalkonium chloride, sodium hydroxide |
Interaction
No studies of the use of the drug Combigan with other medicinesll was not carried out.
However, in no case should not simultaneously use the medicine Combigan with MAO inhibitors.
With increased caution, drops should be used with medications that affect metabolism, becausethere is a risk of intensifying the effects of drugs that suppress the human CNS.
Timolol can raise blood pressure when taken with anesthetics. It is also not recommended to combine them with epinephrine, becausemay progress mydriasis. The content of this substance in the blood increases ethanol, cimetidine, and also hydralazine.
In addition, these drops are recommended with caution to use with drugs designed to reduce blood pressure.
Side effects and contraindications
Most often there is congestion of the conjunctiva of the eye, as well as burning of the mucous membrane. In most cases, these symptoms manifested in mild form, which did not require the withdrawal of the medication.
In addition, there were such manifestations as:
- pain in the eye area, corneal erosion, visual impairment, itching of the skin, follicle, mucosal dryness, blepharitis, epiphary;
- hypertrophy, depression;
- headache, drowsiness, syncope;
- increased blood pressure;
- sensation of palpitations;
- dry mouth, rhinitis;
- taste disorder;
- dermatitis, asthenia;
- arrhythmia, lowering blood pressure, tachycardia.
When receiving one of the active ingredients, a number of side effects also occurred. It is not excluded that these conditions appear when taking Combugan.
The manifestations of Timolol include :
- Ptosis, refraction change;
- Decreased libido, dreams in the form of horrors;
- Temporary loss of memory, ischemia, paresthesia, tinnitus;
- Heart failure;
- Raynaud's syndrome, cough, shortness of breath;
- Diarrhea, as well as nausea;
- Alopecia, psoriasis;
- Peyronie's disease, peripheral edema, chest pain.
In case of overdose development, such manifestations as apnea, CNS depression, dizziness, lowering of blood pressure, bronchospasm, headache, cardiac arrest may occur.
When taking the drug in large doses, you should immediately hospitalize a person in a hospital.
Contraindications
The drug is not used in the presence of such conditions as:
- Allergy to any component of the medication;
- Asthma, as well as bronchial obstruction, including anamnesis and severe lung disease;
- Any heart disease;
- The patient's age is less than 18 years.
Caution this agent should be taken when there are conditions such as
- Renal or liver failure;
- Raynaud's syndrome, depression, hypotension, thromboangiitis
- Diabetes, which is accompanied by hypoglycemia;
- Acidosis( metabolic);
- Pheochromocytoma, the treatment of which is not performed.
Pregnancy
In this period of time it is especially important to refrain from taking any medications, including the drug Kombigan. The fact is that the active components of the drug penetrate the placenta, rendering not the most favorable effect on the baby's body.
In addition, it should be remembered that the medicine can have a negative effect on the baby's body. That is why during the therapy should exclude breastfeeding.
Storage
The medicine should be stored at a temperature of up to 30 degrees indoors, where it will be dark, dry and cool enough. As a rule, patients choose a refrigerator for storage.
The drug should not be given to children.
If all the conditions are met, the medicine can be used for one year and nine months. After opening the package, the drug should be used within the for 28 days of .
Price
The cost of a medicine can vary significantly depending on the country where the goods are sold.
Russia
The cost of a medicine in Russia is 643 rubles .
Ukraine
In Ukraine, for this drug, on average you will have to lay 345.43 hryvnia .
Analogues
This medicine has a large number of analogs, among which you can distinguish such as:
- Fotil .It contains timolol maleate. The cost of the medicine ranges from 243 to 360 rubles;
- Trusopter .The composition of the drug is dorzolamide - the main substance of the drug. The average price of a medicine is 476 rubles;
- Kosopt. The composition of this drug includes such active ingredients as timolol and dorzolamide. The cost of the medicine ranges from 900 to 1150 rubles;
- Pilocarpine. This is the cheapest analogue of the original, tk.its price is on average 28 rubles;
- of Azarga. In the composition there is brinzolamide and timolol. The cost of the medicine ranges from 887 to 1098 rubles;
- Timolol. The composition of this drug is timolol. The cost of the medicine is 58 rubles;
- Betoptik. The composition of this drug is betaxolol. The average cost of a medicine is 43 rubles;
- Travatane. The main substance of the medicine is travoprost. The average price for this facility is 786 rubles;
- Xalatan. The active substance of the drug is latanoprost. The average cost for this drug is 897 rubles.
Reviews of
As a rule, people are afraid to use the medicine because of a large list of side effects, however, those who decided to use the remedy note that the drug very rarely causes an undesirable reaction.
It is said that it is very effective against glaucoma. Some even use the drug themselves for the treatment of eye diseases.
To cons, they include the possibility of cardiac arrest. In addition, some of the patients prefer its cheap analogs.
Attention! Reviews of patients who have encountered this medication can be read at the end of the article.
Blitz-tips
- before you drip the drug you need to remove the lens;
- should refrain from the management of transport, as well as works that require increased concentration;
- for the purchase of the drug it is necessary to show the prescription from the treating ophthalmologist;Do not touch the tip of the cornea with the tip of the
- ;
- during treatment should exclude the possibility of drinking alcohol.