Endometrial hyperplasia - a pathological condition in which there is abnormal proliferation of uterine layer. The main reason for starting this process is a hormone imbalance: lack of progesterone and estrogen excess concentration. Pause lesions manage with medication, correcting hormonal.
Norkolut Djufaston and endometrial hyperplasia promote normalization of progesterone, for this reason are often used in therapy.
Content
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Causes and treatment of hyperplasia
- development of pathologies
- As used Djufaston
-
Indications and contraindications
- First step
- Second phase
- The third stage
- The fourth stage
- analogs duphaston
Causes and treatment of hyperplasia
Endometrial hyperplasia developed for various reasons and are diagnosed in women of any age. In this case, glandular and fibrous tissues undergo a number of changes. This occurs due to the following factors:
- lack of the hormone progesterone, provoked by the individual characteristics of the organism or genetic predisposition;
- age-related hormonal changes (climacteric and menopause);
- diseases of the endocrine system;
- a recent surgery in organs of the reproductive system.
Therapy involves tasks such as:
- the suppression of the pathological process;
- cure the disease;
- pain relief;
- normalization of menstrual cycle;
- prophylaxis of malignant tumors.
In the course of conservative therapy used hormonal medications. It can be a means of oral contraceptives, gonadotropin, anti-estrogens.
sometimes used folk remedies for treatment of hyperplasiaTherefore we recommend to read more information on this topic.
development of pathologies
In the normal course of the menstrual cycle under the influence of estrogen changes the uterine layer. This is to ensure that the ovum was easier to implant in him. Genital organ increases the endometrium. It becomes thicker and gets loose structure, thereby improving blood circulation. If fixing the egg did not occur under the influence of progesterone functional layer collapses and leaves during the critical days.
In case of a successful implantation of the ovum, progesterone stimulates the complete maturation of the endometrium. If the body is hormonal failure, reproductive organ tissues begin to grow abnormally and not break at the right time. Consequently, there is a violation of the menstrual cycle, there is a period spotting regulator and observed excessively heavy menstruation after the delay. Significant blood loss leading to anemia, accompanied by dizziness and weakness. Often at the beginning of the disease process it becomes impossible to conceive.
As used Djufaston
Therapy aimed at eliminating hormone deficiency should be competent and well-founded. Take Duphaston hyperplasia must be strictly prescribed by a doctor. The treatment regimen is selected on an individual basis taking into account the need to preserve the reproductive function. In conjunction with this agent may be used candles, which are introduced into the vagina, and drugs having a systemic action.
Duphaston treatment implies the drug from the 16th to 25th day of the cycle. In some cases, 1-2 tablets daily drink with a 5 x 25-th day.
If the abnormality is diagnosed in women during menopause, the daily dose is 2-3 tablets. They are taken from the 5 th to the 25 th day of the cycle or the 16 th to 25 th.
Between the age of perestroika reproductive function fades. estrogen concentration is gradually reduced, the egg output of the follicle becomes impossible. The corpus luteum develops defective, respectively, progesterone begins to be produced in smaller quantities. In this case, even a small concentration of estrogen can lead to pathological changes in the layers of the genitals. And this is due to the need for hormone replacement therapy
The duration of treatment varies from six months to nine months. Every three months, conducted a number of surveys, the results of which the physician decides whether to continue treatment with this drug.
Indications and contraindications
Duphaston treatment is indicated in the following cases:
- endometriosis and various problems with fiber genitals, including hyperplasia;
- Infertility, which has arisen due to a lack of concentration of lutein;
- threatened miscarriage or frequent spontaneous abortions provoked by progesterone deficiency;
- dysmenorrhea;
- secondary amenorrhea;
- dysfunctional uterine bleeding nature.
Despite the high efficiency of the drug, in some cases, taking it is contraindicated. Among the contraindications are the following:
- liver disease;
- allergy active or auxiliary components;
- tendency to itching of the skin;
- excessive body weight.
First step
Once GGE therapy was initiated, it is essential to stop the menstrual cycle. Accordingly, resort to the purpose of oral contraceptives. If the woman's condition is not improving, then spend scraping the mucous layer to carry out diagnostic procedures. In this case, take tissue samples for histological examination.
Spotting is eliminated by use of haemostatic agents. It is recommended for pain to take painkillers. In some cases, treatment includes blood substitutes, drugs that promote the normalization of water-salt balance, and vitamin complexes.
When receiving the allocation duphaston It may take an unusual character, so I recommend to get acquainted with additional information on this issue.
Second phase
After stopping the bleeding begins the second stage of treatment of endometrial hyperplasia. They are used at the same hormones that prevent thickening and abnormal proliferation of the endometrium in the uterus.
By receiving duphaston progesterone concentration increases. This has a positive effect on the condition of genital organ. Taking the drug three times a day. A single dose is 10 mg. Therapy with its use begins with a 5-day cycle, and ends on the 25th day.
If disease development is observed in combination with disruption of the endocrine system, the recourse to the additional administration of drugs from the group of antagonists. Sedatives are taken in the case of psychosomatic diseases. Thus persists causes inflammation and prevent further proliferation of the endometrium.
The third stage
In the next step the primary objective is to restore cyclicity. It is imperative that ovulation has become a regular. As a result, the cycle is completely restored, and the reproductive system begins to function normally. This point is extremely important in the process of treatment of hyperplasia.
Duphaston helps normalize hormone levels, so there is ovulation.
The fourth stage
Due to the fact that the estrogenic effect was eliminated, reproductive function is restored, the disease process is suspended. After ovulation, progesterone begins vigorously generated, which is required for normal menstrual cycle.
Hyperplasia can cause female infertility. Therefore, after the end of the main therapeutic measures recommended at least once every six months to pass examination and ultrasound, to measure the layer thickness of the mother and, if necessary perform scraping. In this period can also be assigned a means of oral contraception. It should be borne in mind that often their components provoke side effects. Selection of this group of drugs is carried out exclusively by the doctor.
analogs duphaston
Similar effects with djufaston has Norkolut. This drug helps to accelerate the disintegration of estrogen and thereby reduces their concentration. Wherein the amount of progesterone increased, and abnormal growth of endometrial cells ceases.
Norkolutom therapy is carried out on an individual scheme. Often in combination with prescribed him antibiotics, immunomodulating agents and vitamin complexes. In identifying hyperplasia and brief courses of treatment are in the range of 7 to 14 days. The daily dosage thus is only 1-2 tablets. After uterine bleeding is reduced, taking medication is not discontinued. As a preventive measure it is used on certain days of menstruation.
As a rule, you need to take pills from the 15 th to 25 th day of the cycle. Adjust the dosage, choose the date of commencement and completion of therapy should be a doctor.
Possible side effects:
- the beginning of hair growth on areas of skin that had previously been free of hair;
- loss of hair in the temples;
- acne on the chin, nose and forehead wings;
- oily skin, provoked an intense activity of the sebaceous glands;
- dramatic weight gain.
There are several contraindications to the use of Norkoluta. It is strictly forbidden its reception in the following cases:
- neoplasm suspected onset of a malignant process;
- puberty;
- allergic to the drug components.
Do not take hormonal agent in such cases:
- during pregnancy;
- a history of liver pathology;
- bleeding of unknown etiology;
- renal failure;
- increased blood clotting;
- diabetes;
- elevated blood pressure.
a comprehensive survey carried out before the start of Norkolutom therapy, including inspection on a gynecological chair, assess the state of the mammary glands and the delivery of the analysis to determine the level of hormones. When a woman is in the doldrums, the drug should be implemented with caution. If the desired effect is not achieved, then the therapy using this means is stopped.
One of the important phases of the treatment of uterine hyperplasia layer is a hormone therapy. Often at the same time be appointed by drugs such as Duphaston and Norkolut. These medications can rapidly lead to normal hormone levels and thus stop the abnormal proliferation of the endometrium. Nevertheless, to make independent decisions about using these tools is strictly prohibited. And assign them to select the dosage should only doctor.