Tibolone in menopause: instructions for use, drug analogues

Tibolone refers to a group of anabolic steroids. It is prescribed to women during menopause. By taking this drug can be quickly eliminate unpleasant symptoms, manifested at the time of approaching menopause. Should know right away that it represents Tibolone. Instructions for use are in the package. Her need to learn before you start taking the drug.

Mechanism of action

This medical preparation having androgen, progesterone-and estogennoy activity. With it produced stimulation of the pituitary and hypothalamus. The drug composition hormones are produced in the body between the first and second phases of the cycle.

Closer to the approximation menopause in women decreased concentration of estrogen only. Combined effects makes it possible to start the first phase of the forced synthesis of hormones and suppress the production of progesterone. Due to this hormonal normal and reduced the severity of menopausal symptoms. The medicine is also able to prevent the onset of malignancy, but only in the case of long-term treatment.

Structure and Composition

The active component of the drug acts as tibolone. In addition, the following components are contained in its composition:

• lactose;
• potato starch;
• ascorbyl palmitate;
• magnesium stearate.

The drug is available in the form of flat circular tablets of white color. Their edges slightly beveled.

Indications

Acceptance of the treated group is performed in order to prevent or eliminate the clinical manifestations of menopause, as well as for the purpose of therapy and prevention of osteoporosis. The use of the drug is shown in the following cases:

• hot flashes;
• excessive sweating;
• mood swings;
• decreased sexual desire;
• weakness;
• dry mucous membranes of the vagina;
• the appearance of pain during intimacy.

Dosing and Administration

Tablets should be taken once during the day. It is recommended to carry out this procedure at one and the same time, closer to bedtime, and drink water in sufficient quantities. Therapy continuous, cyclical or with minor interruptions. The course of treatment involves taking the drug for three months.

From the use of the drug should be immediately refuse in cases of the following changes:

• severe headaches;
• vaginal bleeding of unknown etiology;
• disruptions in the heart, kidneys and liver.

In case of overdose there is a violation of GI function. It is noted retching, nausea, diarrhea and pain in the abdomen. In addition, there are manifestations of allergy on the skin. Therapy, in this case completely stopped or reduced dosage.

Begin taking medication, a year after the end of menstruation. Therapy in the earlier period can lead to onset of bleeding. Similar changes are also seen in non-systematic use of drugs. Therefore, in cases where the woman drinking a tablet forgotten to take it as soon as possible. If you have already passed the day, just take the next on the schedule.

Medication is not addictive, but a break between courses made compulsory. The influence of the treated group to the bone. Also, during therapy need to monitor the activity of the kidneys, pancreas and liver.

Contraindications

The drug has a powerful effect. From taking it should be abandoned in the following cases:

• during pregnancy and breastfeeding;
• the presence of malignancy or an increased risk of their occurrence;
• bleeding from the vagina, regardless of etiology;
• hypersensitivity to components of medical equipment;
• thrombosis;
• heart failure;
• bacterial endocarditis flowing in subacute form;
• thrombophlebitis;
• disturbances in the synthesis of hemoglobin;
• extensive injuries;
• excessive body weight;
• conducting an extensive operation, accompanied by prolonged immobilization;
• otosclerosis;
• Endometrial hyperplastic processes (both in the present and in the past);
• liver disease;
• bronchial asthma;
• period of less than a year since the last critical days;
• renal insufficiency.

Under strict medical supervision reception is conducted in the presence of disturbances in the gastrointestinal tract, kidneys and heart.

Side effects

Tibolone, like its counterparts in the first few months of therapy may cause the following side effects:

• nausea;
• loss of appetite, or on the contrary, excessive craving for food;
• sleep disturbances, manifested in the form of insomnia or hypersomnia;
• diarrhea;
• pain, localized in the abdominal area;
• dizziness;
• the unpleasant aftertaste in the mouth;
• weakness;
• headache;
• irritability;
• hyperexcitability of the nervous system;
• swelling;
• blurred vision;
• pain in the joints;
• weight gain. Body weight changes rapidly and without cause;
• depression.

Typically, these problems are observed during the first three months of taking the drug. After this time period the state of their own normal. If symptoms are expressed excessively bright, treatment should be stopped. It is necessary to consult with your doctor. Most often carried substituted medicament having a similar effect.

Interaction with other drugs

The instructions to the drug does not say that it should not be taken in combination with other drugs. However, it is noted that the Tibolone enhances fibrinolytic activity of the blood and thus potentiates the effect that coagulants. Moreover, the drug contributes to lowering in glucose tolerance and thereby increases the need for hypoglycemic medication group.

It is noted that drug activity is reduced in case of receiving in conjunction with the following medications:

• rifampin;
• carbamazepine;
• barbiturates.

Treated group revealed the impact on the pharmacokinetics of midazolam.

analogues of funds

Among the analogues of the drug Tibolone are the following:

• Livial;
• Angelique;
• Lebidon;
• Femoston;
• Tsikloproginova;
• Klimodien;
• Divina;
• Klimonorma.

As pointed out by numerous reviews, in their application as possible to achieve the desired result. In this case, replacement of one drug to another without the consent of your doctor strictly prohibited. The drug is selected on an individual basis after due diligence.

Tibolone is effective medication medium capable eliminate unpleasant symptoms typical of menopause. In the systemic application it has been a significant improvement. Menopause occurs with the minimum number of clinical manifestations. The main thing is not to resort to self-medication and agree on the tactics of therapy with a gynecologist.