Ovarian hyperandrogenism: that is, the causes, symptoms and treatment

ovarian hyperandrogenism is a common endocrine disease. This state gynecologists diagnosed in 4-5% of patients. It occurs when the female body male sex hormones produced by the ovaries begin to excess.

Types and causes of the syndrome

Gynecologists isolated adrenal hyperandrogenism, ovarian and mixed origin. Pathology may be hereditary or acquired in nature. It is the primary and secondary.

Most often, ovarian hyperandrogenism occurs in such diseases:

• Primary polycystic ovaries, which is formed in adolescent girls;
• Polycystic ovary syndrome (polycystic secondary);
• gipertekoz, it becomes the cause of hyperandrogenic symptoms in postmenopausal women.

Hyperandrogenism occurs when the body is produced by excessive amounts of androgens or their observed increased production of the hormone androgen precursors. Said diagnosis is as if with normal concentration of androgen sensitivity of target tissues increases them.

Attention! In rare cases, the pathology occurs due to the fact that a woman's body is lowered levels of globulins, which are necessary for the binding of sex hormones.

Globulins are necessary to prevent the interaction and specific androgen receptors. Symptoms of androgen may appear in tumors of the ovary. There are certain forms of cancer for which there is hypersecretion of androgens.

The symptoms of hyperandrogenism in women

Hyperandrogenism in patients accompanied by the appearance of extensive list gynecological, cosmetic and dysmetabolic characteristics. Suspected pathology can develop in such symptoms:

• violation of the regularity of the menstrual cycle;
• amenorrhea;
• anovulatory menstrual cycles;
• the defeat of the skin, most often women complain of acne, dry skin with scaly patches, seborrhea, alopecia;
• girustizm (increased hair growth in male pattern);
• appearance overweight;
• impaired glucose tolerance;
• amyotrophy;
• brutalization vote.

Hyperandrogenism in congenital anomalies of genital organs. At gynecological examination the doctor can identify the hypertrophy of the clitoris, partial fusion of the urogenital sinus, the labia majora.

Most often, the pathology is detected when women turn to the gynecologist for infertility. Some detected weakly expressed hyperandrogenism of ovarian origin. In this case, external changes can not be, and the level of androgens in the blood is within normal limits. For more accurate diagnosis of the patient is assigned to a comprehensive medical examination.

Diagnostics

To install the gynecologist diagnosis:

• collects history;
• conducts inspection and bimanual examination;
• appoints ultrasound diagnostics;
• It gives direction to the blood, urine.

The patient is necessary to determine the concentration of steroid hormones in the body. Surrender recommend tests to determine the level of:

• testosterone (total, free);
• DHEA-S;
• DHT;
• ASD;
• GTN.

When ovarian hyperandrogenism genesis observed increase in ASD and testosterone. Excessive levels of total testosterone or DHEA-S may be indicative of tumor development that synthesizes androgens.

In polycystic ovary syndrome should not only see the content of male hormones, but also to check the overall hormonal balance. The pathology is accompanied by:

• equilibration of testosterone and luteinizing hormone;
• content decrease follicle stimulating hormone;
• increase in prolactin concentrations.

When the disease there is an increase in blood glucose. The diagnosis can be set only by an experienced gynecologist, taking into account survey data, instrumental examination, information collected from the patient's medical history and test results.

therapies

Selection tactics of therapy should be carried out by the attending gynecologist, taking into account the underlying disease, which led to the development of hyperandrogenism syndrome.

If polycystic ovarian hormone therapy is chosen. Patients with girustizomom may appoint Medroxyprogesterone, spironolactone. If patients need to pick up oral contraceptives that have an anti-androgenic effect. gynecologists prescribe Diane-35 often. Under the influence of hormonal pill inhibits ovulation process, the production of gonadotropins, inhibits the production of ovarian hormones. As a result of androgen receptors are blocked, not raised testosterone and SHBG.

Patients who have developed hyperandrogenism in postmenopausal appoint Klim. In identifying androgensekretiruyuschih malignant ovarian tumors treated must select gynecologist oncologist. Most patients prescribed surgery, chemopreventive and radiation therapy. When benign tumors that produce androgens, surgical removal.

Attention! Women with overweight prescribed diet and exercise. Weight reduction helps to normalize hormonal levels.

Forecast

Many women, when correctly chosen tactics of treatment, it is possible to stop ovarian hyperandrogenism genesis. If polycystic ovarian good results are observed during the conservative therapy. Correctly chosen treatment can restore ovulation, normalize the menstrual cycle regularity. If conservative therapy is ineffective, prescribe ovarian electrocoagulation.

In the treatment of hyperandrogenism not only normalizes the reproductive organs, but also reduced cosmetic defects. They may also be resolved by cosmetic manipulations. But they will be effective provided that the woman is undergoing treatment aimed at getting rid of the underlying pathology.

ovarian hyperandrogenism occurs in patients with hormonal disorders which have arisen on the background of polycystic ovarian tumors or gipertekoza. Treatment should be chosen gynecologist after a full examination of the patient and clarify the causes that provoked the appearance of hyperandrogenic symptoms. Learn how to manifest androgen what tests are necessary for the diagnosis, as the treatment is carried out, it is possible from the video