Low molecular weight heparin Fraxiparin: indications, instructions, testimonials

Nadroparin calcium( trade name Frakssiparin) is often used to treat various thrombotic diseases, as well as the prevention of disorders associated with cardiac activity. Because this medicine is strong, its use is only possible according to the doctor's prescription.

The drug refers to drugs with an anticoagulant effect. This tool prevents the appearance of blood clots, so it is often used to treat and prevent thrombosis of superficial and deep veins.

Also, the drug is actively used for the therapy of other dangerous vascular disorders.

Form release and component components of

A drug is produced in the form of a solution whose structureColorless or has a light yellow color. The solution is placed in syringes. The drug is intended for injections under the skin.

Syringes with solution are placed in blisters. One blister can contain one, two or five syringes, which are placed in packs of cardboard.

Frakssiparin consists of the following components:

1. The main component of is calcium supraparin. Its dosage can be the following - 2850, 3800, 5700, 7600, 9500 IU anti-Xa.
2. Additional components - hydrochloric acid, calcium hydroxide solution, water for injection.

Pharmacological properties of

Fraxyparin is part of the anticoagulant group with antithrombotic effect. Nadroparin calcium is low molecular weight heparin, which is obtained by depolymerization from conventional heparin. If we consider this substance from the chemical side, it is glycosoaminoglycan, whose molecular weight is 4300 daltons.

This component has increased tropicity to the blood protein antithrombin 3, which as a result leads to a decrease in factor Xa. This condition causes the severity of the antithrombotic effect of the supraparin.

Other principles of increasing antithrombotic activity consist of stimulation of the tissue factor inhibitor, enhancement of fibrinolysis due to direct release of the tissue plasma plasmogen activator from endothelial cells, and also from the modification of hemorheological data - decrease in the level of viscosity of the blood structure, increase in the number of platelets, change in the granulocyte membrane.

Compared to heparin, the unfractionated type has the lowest effect on platelet activity, on the form of aggregation, and on the state of primary homeostasis.

During therapy with high activity, an increase in APTT by 1.4 times the standard can be observed. If it is used in preventive doses, then there is no strong decrease in APTT.

During the administration of the drug by subcutaneous injection, the maximum concentration in the blood is reached within 4-5 hours. Absorption of the drug occurs up to 88%.During intravenous administration, the highest concentration is observed after 10 minutes.

The elimination half-life is approximately 2 hours. Metabolization of the drug is predominantly observed in the liver by desulfated methods or by depolymerization.

For which indications should the drug

be used Fraksiparin is intended for use in the following diseases:

• for the prophylaxis of thromboembolic diseases, during operative surgical and orthopedic operations, in the presence of an increased probability of formation of thrombi in conditions of ICU, which are accompanied by respiratory or cardiac insufficiency in acute form;
• at risk of development of PE;
• for the elimination of thromboembolic symptoms;
• for prophylactic treatment of blood clotting during hemodialysis procedures;
• for the elimination of unstable angina and myocardial infarction without a tooth Q.

Contraindications and limitations for prescribing

Fraxyparin should not be used in the following conditions:

• if there are severe bleeding with an increased risk of their reappearance, which is associated with worsening homeostasis;
• the presence of thrombocytopenia that occurred during the administration of Heparin in the past;
• presence of organ disorders that are associated with a risk of bleeding;
• adolescents under the age of 18;
• if there is severe renal failure;
• risk of intracranial hemorrhage;
• presence of lesions due to surgery on the spinal cord or brain, as well as on the eyeballs;
• presence of infective endocarditis in acute form;
• if there is a high sensitivity and individual intolerance to the substances that make up the medication.

How to prick Frakssiparin - rules, regimens, dosages

The solution is injected under the skin. When administered, the patient must lie down. The drug should be injected under the skin into the anterolateral or posterolateral abdomen. The drug is injected into each side in turn - first to the right, then to the left. You can also enter into the thigh.

The needle is inserted under the skin in a perpendicular position, but not at an angle. Before the introduction, the skin should be caught in a small crease. It is formed in the gap between the thumb and forefinger. Place the folds to be held throughout the entire injection of the drug. After the injection, the area where the medication was administered should not be ground.

Features of the use of Nadroparin depending on the purpose:

1. During the treatment of thromboembolism with and immediately after surgical procedures, it is recommended to administer Fraxiparin solution at a dose of 0.3 ml or 2850 IU of anti-Xa, it is done by subcutaneous injection. The medication is injected 2-4 hours before surgery and after that once every 24 hours. Treatment should last at least a week, and can be carried out until the time when there is an increased risk of blood clots.
2. During the period of prophylactic therapy of thromboembolism in orthopedic surgical interventions , the injection is administered by subcutaneous administration at dosages based on the total body weight, a dose of up to 38 IU of anti-Xa is needed per kilogram of patient mass. On the 4th day after surgery, the dosage can be increased to 50%.The first administration of the drug should be performed 12 hours before the surgery and a second dose is done 12 hours after the operation. After this, the injections of the medicine are made in the entire subsequent period, until the risk of blood clots decreases, and the patient will be transferred to outpatient treatment. The minimum duration of injection procedures should be 10 days.
3. Patients who have a risk of developing thrombus , accompanied by infectious respiratory tract infections, as well as respiratory or heart failure, the drug is prescribed once every 24 hours, it must be injected into the skin. Dosage of the solution is determined depending on the body weight. The drug is administered throughout the period of risk of thrombosis.
4. When treats thromboembolism , anticoagulant drugs should be given immediately after the onset of symptoms. Injectable administration of Fraksiparin is done until the desired prothrombin time is reached. The medication is administered subcutaneously 2 times per 24 hours. The injection is done every 12 hours. The dosage of the solution depends on the body weight - for 1 kg, 86 IU anti-Xa should be administered.

The video shows how to individually prick a Kleksana prick, the injection of Fraksiparin is done similarly:

. Application during pregnancy and lactation.

. According to animal experiments, there are limited data that the constituent components of Fraxiparin penetrate the placenta to the baby,pregnancy time is not recommended, but in practice it is applied.

Sometimes there are exceptions when the benefit for the mother will exceed the risk for the child.

During breastfeeding, the use of the drug is not recommended, since the constituent components can be included in the milk composition.

Side effects of

The following side effects may occur during application of the drug:

• bleeding of various locations;
• state of thrombocytopenia and eosinophilia;
• increase in the level of hepatic enzymes;
• reactions may occur in the form of hypersensitivity;
• at the injection site, hematomas may appear, solid formations that disappear within a few days, sometimes necrosis may develop, in which case therapy is discontinued;
• also rarely appears hyperkalemia and priapism.

Allergy to Fraxyparin injection

Practical experience of application is important

Opinion of professional doctors and feedback from ordinary people about the drug Fraksiparin.

Purchase of the drug and its analogues

The price of the drug is quite high on average for a package with 10 syringes 0.3 is from 2200 and comes to 4020 rubles, per Fraksiparin package No. 10 0.6 ml - from 3400 to 5000 rubles, also available to purchase the following medicinal analogs:

• Angioflux;
• Hemapaksan;
• Fragmin;
• Heparin-Bioloc;
• Clexan;
• Novaparin;
• Flenox;
• Tsibor;
• Enoxarin.