Depo-Provera is one of the first gestagenic drugs that is still used today in gynecological practice for treatment and even for the purpose of contraception, as well as for certain oncological diseases. The drug is very long in the plasma-related condition in the blood, which is why many of its actions and side effects are caused. For example, the depot-check and monthly may be delayed for a long time, and the myoma with endometriosis can be cured, but it can be restored up to a year, and sometimes more, after it. What is a special drug, who is shown and what to expect from it?
What is the preparation
The main active substance of the depot-prodrug is medroxyprogesterone acetate, it seems similar to its effect on gestagens - hormones of the second phasethe woman.
Various forms of medicines and doses are issued, but injections are most often prescribed, they are most convenient from the point of view of the time interval of reception and the effect.The therapeutic effect of the depot is due to the following effects:
- It inhibits the production of gonadotropic hormones in the pituitary gland LH and FSH, which affects the growth of follicles, resulting in complete suppression of ovulation. As a result, many hormone-dependent diseases do not progress, and even gradually their manifestation significantly decreases.
- De-provera negatively affects the growth of the endometrium, which is used to treat the pathology of the uterine cavity.
- Increases the properties of cervical mucus, which additionally forms a kind of barrier to penetration of spermatozoa.
Some undesirable effects of the drug are due to its pyrogenic effect, i.e.when you receive a body temperature increases, but it does not reach critical values. Also, the depot-provera has mineralocorticoid activity. This can cause the development of the Itenko-Cushing syndrome with prolonged use.
The peculiarity of the drug is that it penetrates the blood-brain barrier, i.e.in the structure of the brain, and also through the placenta( if taken suddenly during pregnancy, although this is contraindicated) and in breast milk. This should be taken into account when applying it.
We recommend that you read an article about menstruation when taking birth control pills. From it you will learn about daily and emergency contraception, its effect on menstruation, the peculiarities of using certain drugs.Indications for use
Depot-probe is used in various fields of medicine. So, the indications for its application are as follows:
- In oncology practice with breast cancer, endometrium, prostate, kidney and some other conditions.
- In gynecology for the treatment of endometriosis, uterine fibroids, chronic endometritis, endometrial hyperplasia, polyposis.
- It is also possible to use depot-check for contraception in women who do not plan a pregnancy within the next year or two.
- The drug is indicated for the correction of menopausal disorders in women, such as hot flashes, fever, sweating, and the like.
Look at the video about contraceptives:
Contraindications
The drug can not be used for allergic reactions to this and other similar means. Also contraindications are the following situations:
- During pregnancy and breastfeeding, as the depot-provera penetrates through all barriers and can adversely affect the development and growth of the baby.
- Given that the drug is metabolized and excreted through the kidneys and liver, it should be used with extreme caution when the work of these organs is disrupted.
- For ever established epilepsy, migraine, bronchial asthma, serious cardiovascular disorders, the drug should be used only in extreme cases.
- If the agent is prescribed for a contraceptive purpose, as well as for the treatment of non-malignant neoplasms, it is necessary to exclude possible hormone-dependent tumors.
- Also, in the presence of diabetes, the drug can affect the degree of effectiveness of essential medicines.
- Since Depo-Provera can contribute to the development of depression, it should not be used in severe cases of this disease.
- When the blood clotting abilities are violated, as the drug increases the likelihood of blood clots.
Features of
Depo-Provera can be used in the form of tablets, as well as spray or intramuscular injections. The latter form has found the greatest application in gynecology.
Doses and regimens in oncology practice are characterized by a greater dosage and less intermissions between doses. This is necessary in order to create an overwhelming malignant growth in the concentration of the drug in the blood.
When used in gynecology, the following options are used:
- for the purpose of contraception is prescribed 150 mg of the drug for three months;
- for the treatment of endometriosis dose increase to 50 mg every week or 150 times in two;
- during the period of the formation of menopause or already during it is used 150 mg of the drug for 12 months, if necessary, the course is repeated.
The following can be distinguished from the main ones:
- Anovulation and prolonged suppression of hypothalamic and pituitary function. Therefore, the monthly after the depot-probe can be absent for a long time.
- Change in body weight. Many women claim to have significantly increased weight, but there is no reliable statistical data on this. In most cases, the set of body mass is due to the natural aging processes, and also as a result of lifestyle changes.
- Sometimes there are mental disorders, especially in patients who are predisposed to it. In addition to depression, decreased libido, irritability and some other symptoms, there may even be a decrease in attention and concentration, migraine, etc.
- Often there are acne, hirsutism, hair loss and others.
- Some disorders can also occur in the cardiovascular, digestive, urinary, endocrine and immune systems.
Monthly after the preparation of
It is often enough to encounter a situation when there is no monthly depot after the injection of the depot, and to this the woman may not be quite ready. Such situations can be caused by the following:
- If large doses of the drug are used, which is typical for the treatment of oncological diseases. In this case, it takes a long time to restore its own production of FSH and LH.
- With hypophysia and hypothalamus hypersensitivity to the drug. Monthly can not be restored for a long time even after one injection.
- If the liver and kidney function is disturbed, when the depo-probe is more slowly withdrawn, then it can remain active for more than a year. This is observed when it is accumulated in the adipose tissue of a woman, from where it then gradually enters the bloodstream.
- If the period of taking the drug coincided with the onset of menopause in women, including early. Or he may even speed up its approach somewhat. In this case, after taking the medicine, the monthly ones can not be restored only if an artificial hormonal background is created with the help of hormone replacement therapy( HRT).
The following monthly disturbances are permissible against the background of a depot-probe:
- periodic spotting for several months and the absence of normal critical days;
- breakthrough bleeding;
- absence of menstruation up to 6 months or more, in this case, it is necessary to exclude pregnancy.
Chances of conception of
Young women are often interested in the question of how the months go after the depot-check, and when it is possible to plan pregnancy. In most cases, follicle maturation and ovulation begin from the second to the third month after the drug is discontinued. But it is possible that more time will be required.
If a woman is very interested in pregnancy, it is possible to correct the hormonal background with the help of estrogens and gestagens at the discretion of the doctor. Schemes are individual in each case.
We recommend reading the article on bleeding when taking birth control pills. From it you will learn about the effect of oral contraceptives on the woman's body, the causes of the ointment during the ovulation period, and the causes of bloody discharge. Depo-Provera is one of the effective drugs for the treatment of various gynecological pathologies. The drug can have a significant effect on the work of the hypothalamic-pituitary system and lead to various violations of menstrual function. Own monthly and the possibility of pregnancy is restored on average 2 to 3 months after the end of the use of the drug.