Novelty in the market of venotonic and angioprotector Detraven

Drug drug Detraven, due to its active substance belongs to the group of angioprotectors.

The drug is produced in tablets and its main constituent is a mixture of two flavonoids of diosmin and hesperidin in a ratio of 9: 1.

One capsule contains, respectively, 450 mg of the first substance, and 50 mg of the second.

Pharmacological action

Diosmin and hesperidin areflavonoids of plant origin. Their action is aimed at eliminating stagnation in the veins, which is formed for a number of reasons:

• sedentary work.
• overweight.
• lack of physical activity.

During the reception of the drug, tone and microcirculation of blood are restored in both large and small vessels. After the course of treatment elasticity and plasticity returns to the capillaries. Due to such improvements, their fragility decreases, lymph drainage and lymph drainage from the lower limbs are established.

The drug does not admit the adherence of leukocytes to the vessel wall. This helps reduce the effect of mediators of inflammation on the valves of the veins.

Pharmacokinetic profile

Because the pure flavonoid fractions of the main active ingredients of diosmin and hesperidin are in the form of micronized particles, the absorption of the drug and its effect begins very quickly.

Pharmprofile media:

1. Suction .When ingested in the gastrointestinal tract, the diosmin undergoes processing by the parietal microflora. The result of of this process is the fat-soluble aglycon of diosmetin. He gets into the bloodstream. Diosmin forms, which have not been processed, can not be absorbed into the blood.
2. Distribution of .With blood flow, diosmin is rapidly distributed throughout the body. During the animal tests, diosmin was labeled with a radioactive label. This made it possible to draw a conclusion about the wide distribution of its metabolites throughout the body.
   Already in 1-3 hours after the internal use of the drug, you can observe its maximum concentration in the blood.
3. Metabolism .By definition, in the urine of a patient with different phenolic acids, one can judge the extensive metabolic processes of the drug.
4. Breeding .The half-life of the drug is no more than 11 hours. Only 14% of all metabolites are excreted in the urine. The main amount of the drug taken enters the intestines and leaves the body together with the feces.

Scope of application

The main reason for prescribing the drug is its use in the complex therapy of varicose veins, which is characterized by:

• severity of the lower limbs;
• swelling of the feet;
• pain in the legs;
• disorders of tissue trophism.

It is also used in the complex therapy of manifestations of internal and external hemorrhoids.

The only contraindication to the use of the remedy are allergic reactions to the main components of the drug.

Side effects and cases of overdose

During clinical trials, as well as in the analysis of patients' reviews, Detraven was able to identify the presence of the following side effects that can occur when taking the remedy:

• headache;
• dyspeptic reactions( nausea, vomiting, diarrhea);
• poor general state of health, which is manifested by malaise and dizziness;
• skin reactions in the form of rash, itching, urticaria;
• edema of the lips, face or eyelid;
• in very rare cases reported on the development of angioedema.

To date, there has been no information on overdose cases, which indicates a high safety of the drug.

Method of taking and dosage

According to the instructions, Detraven tablets are prescribed in various doses that depend on the disease and its complexity:

1. When diagnosed with , chronic venous insufficiency and varicose disease use a dose of 2 tablets. The interval between receiving each of them is approximately 12 hours. After 7 days, in the absence of adverse reactions, the doctor allows one time to take both tablets at a time convenient for the patient( preferably in the morning).
2. Treatment of acute form of hemorrhoids begins with taking 6 tablets per day. This schedule must be observed for 4 days. The next 3 days should take 4 tablets of medicines per day. It is worth noting that the dose is divided into 2-3 receptions.
3. Chronic hemorrhoids begin to be treated by prescribing the drug 1 tablet twice a day. After 7 days, you can combine 2 tablets of the drug in a single dose.

The drug should be taken with food. The duration of treatment is determined by the doctor. His decision depends on the neglect of the disease, its characteristics and individual perception of the drug by the patient. Most often the patient takes the drug for at least 3 months.

Tips for the therapy of

Therapeutic measures to eliminate acute hemorrhoids do not produce only by taking this medication, local treatment of the anorectal area is also necessary.

Detraven is prescribed for such purposes for only a few days and is observed for the disappearance or decrease in symptoms of hemorrhoids. If the treatment scheme does not work, the patient is sent for an additional examination and is assigned a change in the tactics of conducting medical care.

In turn, in order to treat varicose veins and bring the venous circulation back to normal it was very important to reconsider your lifestyle. Namely:

• do not stay in the sun for long;
• bring the weight back to normal;
• do not stand for long on your feet and do not wear high heels;
• stroll slowly, this will help improve blood circulation;
• wear compression knitwear;
• in the evening, massage the lower extremities with cool water using a shower head;
• unquestioningly follow all the doctor's recommendations.

Special patient groups and situations

Use of the drug to treat children under 18 is prohibited. During clinical trials, teratogenic effects on the fetus are not proven. However, when Detraven is appointed, it is worth comparing the benefit to the mother and the risk to the child.

There is no information on the penetration of the drug into breast milk, so these tablets are not used during lactation.

During the reception of the drug in the patients there were no deviations in the rate of reactions, therefore it is allowed to drive the car and work with other mechanisms during the treatment.

Studies on the interaction of Detraven with other drugs have not been conducted.

Opinion of patients and doctors

Detraven fell in taste to both doctors and ordinary sufferers, which is confirmed by the reviews.

Purchase and storage of

The drug is produced in Belarus and prices will be given for this country. The price policy of pharmacies for Detraven is different, you can pay for a drug in Minsk:

• for 450 mg package + 50 mg No. 30 8.43( 84300) - 11.50( 115,000) rubles;
• for packing 450 mg + 50 mg No. 60 17( 17000) - 22.27( 222700) rubles.

Shelf life 2 years from the date of manufacture. Store the drug in a dark place and at a temperature of no higher than 30o C.The product is on sale and is released from pharmacies without a prescription.

The drug Detraven has analogues of both European and Russian production, among them:

• Detralex;
• Diophlan;
• Normoven;
• Avenue;
• Phlebotens plus;
• Venarus;
• Venozol;
• Vasoket;
• Flebodia;
• Diovenoor;
• Proven;
• Daflon.