Normov refers to the pharmacological group of cardiovascular, angioprotective drugs.
According to the ATS-classification has the number of C05C A53 and refers to capillary stabilizing means .
The active components of the medication is diosmin and hesperidin. It produces the drug Kiev Vitamin Plant.
Content
- Product form
- Composition medication
- Therapeutic effect
- Impact on the veins and the body
- Indications reception
- Contraindications
- Clinical trials
- principle of drug action
- Dosage
- drug Cautions
- reviews of people about the drug Normoven
- Recommendations
- Pros and cons
- Costmedicines
- Conclusions
Form release
Produced in the form of tablets, in blisters for 30 and 60 pieces per package. One tablet contains 450 mg of diosmine and 50 mg of gesperedin.
The tablets themselves are rounded in a brown-yellow shell.
Composition of the drug
Tablets Normoven Contain:
- Diosmin is an angioprotective and venotonic agent. It is able to reduce the extensibility of veins, the permeability of capillaries, to reduce venous congestion. This increases the tone of the vessels, improves lymphatic drainage, microcirculation of blood. There is also an anti-inflammatory, anti-edematous effect, a reduction in the number of superoxide anions, blocking the production of free radicals and the synthesis of prostaglandins. Diosmin does not penetrate the hematoplacental barrier. This allows you to take diosmin-containing drugs during pregnancy and lactation.
- Hesperidin - bioflavonoid, which has a tonic effect on the veins. Has spasmolytic activity, dilates blood vessels, activates the production of collagen, improves the properties of connective tissue, normalizes the rheological properties of blood. Medicines containing hesperidin are taken during chronic venous insufficiency and hemorrhoids.
Therapeutic effect
The instruction for use indicates that Normoven reduces the increased vascular-tissue permeability, prevents venous congestion and thrombosis .
There is a decrease in adhesion of leukocytes to the venous endothelium, activation and release of leukotrienes, proteolytic enzymes and cytokines into the blood.
Effects on the veins and body
During the administration of Norman, a decrease in the destructive effect of inflammatory mediators is observed, during which the 
valves of the venous valves are damaged, by reducing the interaction of the endothelium and leukocytes.
Over time, the patients regularly taking the drug disappears feeling of heaviness, fatigue, pain and tension in the legs.
Normoven perfectly copes with peripheral edema.
Indications for reception
The drug is generally prescribed for such diseases and conditions, as:
- hemorrhoids( acute or chronic form);
- chronic venous insufficiency;
- trophic ulcers;
- nocturnal cramps;
- swelling, pain, feeling of heaviness in the lower limbs.
Contraindications
Normoven is well tolerated by patients except for some cases:
- hypersensitivity to some components;
- pregnancy and lactation, as there have not been clinical trials;
- child's age.
Clinical Trials
In 2006, in the surgery department of the Institute of Surgery and Transplantology of the Academy of Medical Sciences of Ukraine, a study was conducted that proved that Normoven has high therapeutic effectiveness not only in the treatment of CVI, but also in the postoperative period, in particular, after interventions on the carotid artery.
It has also been shown that the drug is able to optimize the intrauterine state of the fetus in varicose veins, to be effective in treating patients with venous distension.
Principle of the drug
The pharmacological effect of the drug occurs due to the stabilization of lysosomal membranes, the reduction of the released autolytic cell enzymes, which in turn are capable of splitting proteoglycans.
Transcapillary filtration of low molecular weight proteins also decreases.
When metabolized, the drug forms phenolic acids. Active substances accumulate in the subcutaneous veins of the legs, as well as in a smaller volume - in the kidneys, liver and lungs.
The elimination half-life is eleven hours. Diosmin accumulates in the tissues of the vessels for 96 hours. The drug is excreted by the kidneys, intestines and bile.
Dosage of the preparation
Instructions for the tablet Normoven indicates that:
- During chronic venous insufficiency or for the prevention of relapses of acute hemorrhoids, one tablet is administered twice a day, in the morning and in the evening, while eating. Duration of treatment is chosen individually and depends on many factors( efficacy, tolerability, etc.).
- In acute conditions, ( hemorrhoids) take six tablets, for the first four days and four in the following days. Treatment usually at such dosages is short and passes under the close supervision of the doctor.
Special instructions
In acute forms of hemorrhoids, Normoven does not replace the specific treatment of the anorectal area.
Removal of the drug is not required if there are minor disorders of the digestive and vegetative-vascular system.
Gel Girudoven for the prevention and treatment of varicose veins: instructions for use and other useful information in our article. In what cases is vein striping used and what does the procedure involve? What complications and consequences can be after stripping.
Reviews of people about the drug Normoven
Let's study the responses of doctors and patients about the drug Normoven.
This puts me before the task of finding a universal and effective means. I can say with confidence that I decided this task 5 years ago when I met Normoven. Its low cost, a small number of side effects, and most importantly the effectiveness made it number one in the frequency of prescribing it to my patients.
Dmitry Anatolyevich, angiologist.
But, no matter what, the attacks arose and very painful. Then, at one of the consultations, the doctor advised taking Normoven.
I accept it for about two months, no aggravations have occurred during this time. Moreover, I feel that my chronic illness will soon go away.
Ekaterina, 46
Literally after a month of taking the drug, the pain symptoms have disappeared, the veins do not progress.
Elena, 34
Recommendations
In case of allergic reactions, discontinue use of the drug and immediately consult a doctor. 
Because interactions with other drugs are not described, it is implied the possibility of simultaneous reception of drugs of different groups.
However, doctors should be warned about the medications taken.
Pros and Cons of
Pros:
- is relatively low cost;
- high efficiency;
- has a small number of side effects.
Cons:
- is a rarity in pharmacies in Russia;
- a small number of tests.
The cost of medicine
Normoven can be purchased at pharmacies in Russia, online pharmacies, the average price of 400-600 rubles for 60 tablets.
Conclusions
Normoven is an effective, inexpensive preparation of used in the practice of varicose veins, hemorrhoids and some other conditions associated with disruption of the human vascular system, especially the vessels of the legs.
A distinctive feature of the Normoven active components is that they accumulate, mainly, in the tissues of the lower limbs. This makes it more effective for the treatment of leg ailments.