Hepatoprotectors are drugs that promote the normal functioning of the liver and protect its cells from the negative effects of poisons and toxins. The list of these medicines includes both natural medicines and synthetic ones. Not all of them have proven efficacy through clinical trials, but are often prescribed by doctors as preventive or adjuvant to improve liver function.
- As operate
- esential phospholipids
- phospholipo( Lecithin)
- Fosfontsiale( Naturkarsevt)
- Ijssel Forte
- Essentiale H( Essentiale Forte H)
- Essliver Forte
- Drugs of plant origin
- Gepabene
- Karsil( Silibinin, Silimar)
- Hofitol
- Homeopathic remedies
- Halsten
- Hepel
- Bile acid preparations
- Ursofalk( Urdoksa, Ursosan, Holudexan, Exhol)
- Preparations of amino acids
- Hepa-Merz
- Heptral( Heptor)
- Preparations of animal origin
- Hepatosan
- Progepar
- Sirepard
How the
works Depending on the origin and impact on the body, the following groups of hepatoprotectors can be distinguished:
- Essential phospholipids .They are a highly purified extract of soybean beans containing phosphatidylcholine and unsaturated fatty acids. Molecules of substance are built into the structure of damaged liver cells, replace defects and restore barrier function of membranes. Also, phospholipids affect the cellular metabolism, enhancing the detoxification capacity of the liver, and exhibit antioxidant properties, reducing the rate of free radicals.
- Amino acids .They participate in the synthesis of phospholipids and biologically active substances, have a regenerating and detoxifying effect, break down fats and remove them from the liver. The effectiveness of such drugs has been proven in the case of intravenous administration, while the intake of oral forms, according to most physicians, does not affect liver cells.
- Bile acids .They are used to treat diseases of the liver and biliary tract, dissolution of gallstones, lowering of cholesterol in bile. They are very effective, but they differ in a large number of contraindications, as well as immunomodulating properties, so unauthorized use of such drugs can be dangerous.
- Means of vegetable origin .More than half of the hepatoprotectors belong to this group. Due to their natural nature, they have the least toxic effect on the body. Phytopreparations stimulate the restoration of liver cells, protect it from the effects of alcohol and other harmful substances, normalize the function of protein synthesis, have a cholagogic effect, improve the digestion process. The most effective drugs are considered on the basis of silymarin - a flavonoid compound contained in a thistle spotted.
- Means of animal origin .Synthesized from liver pigs and cattle. They have protective, detoxification and antioxidant activities, stimulate the regeneration of the liver parenchyma. The effectiveness of these drugs is indisputable, but they have a lot of contraindications and a great allergic potential. It is also possible to infect a patient with a prion infection.
- Vitamins( E and Groups B) .Participate in metabolic processes, have protective properties. With a deficiency in the body of these substances, clotting of blood is disrupted, and the life span of liver parenchyma cells - hepatocytes is reduced.
Essential phospholipids
to contents ^Phospholip( Lecithin)
The active ingredient is lecithin( phospholipids).Form release - capsules.
It is indicated for fatty liver degeneration( including diabetes mellitus), cirrhosis and toxic liver damage, chronic and acute hepatitis, toxicosis of pregnant women, psoriasis, radioactive syndrome. It is used before and after operations on the liver and biliary tract.
The initial dose of intake is 2 capsules 3 times a day, supporting - 1 capsule 3 times a day. The recommended course is 3 months.
Side effects: gastrointestinal disorders, allergic reactions.
Phosphontsial( Naturkarevt)
Active substances - phospholipids, silymarin. Form release - capsules.
Included in the complex therapy for poisoning and intoxication, liver cirrhosis, radiation sickness, gestosis, hepatitis, psoriasis, lipid metabolism disorders.
Depending on the disease appoint 1-3 capsules 2-3 times a day with a course of treatment from 10 days to 3 months. For prevention, take 1 capsule 2-3 times a day for 1-3 months.
Side effects: nausea, stomach pain, allergic manifestations.
Essel-Forte
Active ingredients are essential phospholipids, nicotinamide( vitamin B3), pyridoxine hydrochloride( vitamin B6), riboflavin( vitamin B2), thiamine mononitrate( vitamin B1), cyanocobalamin( vitamin B12), tocopherol acetatevitamin E).Form release - capsules.
It is used for diseases of the liver and biliary tract. Drink 2 capsules 3 times a day for at least 3 months.
Side effects: with a tendency to diarrhea, discomfort in the stomach area is possible.
Essentiale H( Essential Forte H)
The active ingredient is phospholipids from soybeans. The form of release - capsules, a solution in ampoules for injections.
It is prescribed for chronic or alcoholic hepatitis and other violations of the liver, for toxicosis of pregnant women, for the prevention of recurrence of cholelithiasis.
Take 2 capsules 3 times a day with meals, with 1 glass of water. At intravenous introduction the daily dose makes 1-2 ampoules, in serious cases - 2-4 ampoules.
Side effects: a feeling of discomfort in the stomach, diarrhea, allergic rashes on the skin.
Essler Forte
Active substances - essential phospholipids, vitamins E, B1, B2, B3, B6, B12.Form release - capsules.
It is used for violations of lipid metabolism, alcohol, drug, drug or radiation damage to the liver, cirrhosis or fatty liver, psoriasis.
Take 2 capsules 2-3 times a day for 3 months, with psoriasis treatment - 2-3 weeks.
Side effects: a feeling of discomfort in the epigastric region, allergic reactions( redness of the skin, itching).
Vegetable preparations
to the table of contents ^Hepabene
Active substances - extracts of herbs of medicinal( Pyrophenol) and milk thistle( silymarin).Form release - capsules.
Refers to phytopreparations with hepatoprotective and choleretic action, normalizes liver function in intoxications and hepatitis, binds free radicals, promotes normal bile secretion, eliminates spasm of the gallbladder and ducts.
Take 1 capsule 3 times a day with water. If necessary, you can increase the dose, but not more than 6 capsules per day.
Side effects: a slight laxative effect, allergic manifestations.
Karsil( Silibinin, Silimar)
The active ingredient is an extract of the milk thistle fruit. The form of release - dragees, tablets.
It is used for toxic liver damage and for their prevention, for correction of lipid metabolism disorders, it is a part of complex therapy for cirrhosis, dystrophy and fatty infiltration of the liver, hepatitis.
Adults and children over 12 years of age take 1-2 tablets 3 times a day, drinking water. In severe forms of the disease, the dose can be doubled. For children 5-12 years, the daily dose is 3 milligrams per kilogram of body weight with breakdown by 2-3 admission.
Side effects: dyspepsia, nausea, diarrhea, allergic reactions( rashes, skin itching), increased vestibular disorders, dyspnea.
Hofitol
The active substance is an extract of artichoke leaves of the field. Form release - tablets, solution for oral administration, solution in ampoules for injection.
Stimulates the production of bile, prevents its stasis in the biliary tract, increases the secretion of pancreatic enzymes. It is used for dyskinesia of bile ducts, chronic cholecystitis, hepatitis, renal insufficiency, poisoning with hepatotoxic substances.
Adults and children over 12 years old take 1-2 tablets or 2.5-5 milliliters of solution 3 times daily before meals, children 6-11 years old - 1 tablet or 2-3 milliliters of solution 2-3 times a day, To children of younger age - from 10 drops to 2 milliliters of a solution 2-3 times a day, a course of treatment - 2-3 weeks. Children from 6 years of age may have intravenous and intramuscular injection of 0.25-0.5 ampoules once a day, children older than 15 years - 1-2 ampoules per day for 8-15 days.
Side effects: nausea, diarrhea, allergic reactions.
Homeopathic remedies
to the table of contents ^Galstena
Active ingredients - milk thistle, dandelion, celandine, sodium sulfate, phosphorus. The form of release - tablets sublingual, drops for reception inside.
It is intended for use in complex therapy for acute and chronic liver diseases( hepatitis, hepatosis), gallbladder diseases( chronic cholecystitis, postcholecystectomy syndrome), chronic pancreatitis.
Take 30 minutes before or 1 hour after meals 3 times a day. A single dose for children under 1 year is 1/2 tablet or 1 drop, for children 1-12 years - 1/2 tablets or 5 drops, for children from 12 years and adults - 1 tablet or 10 drops. If necessary, the frequency of reception can be increased, but no more than up to 8 times a day. The course of treatment is 1-3 months.
Side effects: increased salivation.
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to contents ^Hepel
Active ingredients - milk thistle, spotted clavate, cinchona, celandine, white chamois, nutmeg, colocite, phosphorus. The form of release - a tablet, a solution for injections.
Has choleretic, antidiarrheal, hepatoprotective, antispasmodic, anti-inflammatory activity. It is recommended for conditions such as a violation of appetite, bloating, eczema, acne, polyarthritis, as well as in complex therapy for inflammatory or toxic liver diseases.
Take 1 tablet 3 times a day, dissolving it in the mouth before dissolving, the course of admission - 2-4 weeks. The solution for injections can be administered intravenously, intramuscularly or subcutaneously, in acute cases - 1 ampoule a day, with improvement - 1 ampoule 1-3 times in 7 days.
Side effects: allergic manifestations, jaundice.
Preparations of bile acids
for table of contents ^Ursofalk( Urdoksa, Ursosan, Holudexan, Exhol)
The active substance is ursodeoxycholic acid. Form release - capsules of 250 milligrams, a suspension for oral administration.
Assigned to dissolve cholesterol stones in the gallbladder, with chronic hepatitis of various etiologies, alcoholic liver disease, dyskinesia bile ducts.
The daily dose depends on the severity of the disease and body weight of the patient, and can range from 2 to 7 capsules, divided by 1-3 doses. The course of treatment is from 10 days to 2 years. Patients with a body weight of less than 47 kilograms are advised to take the drug in the form of a suspension, the dosage is calculated according to the scheme of 1.25 milliliters for every 5 kilograms of weight.
Side effects: abdominal pain, diarrhea, hives, itching of the skin.
Preparations of amino acids
for table of contents ^Hepa-Mertz
The active substance is ornithine aspartate. The form of release - pellets for the preparation of solution for oral administration, concentrate in ampoules for injection.
Reduces the level of ammonia in the blood, is used to remove from the hepatic coma, in cases of brain damage caused by liver dysfunction, as well as fatty degeneration and toxic hepatitis.
Take after eating, dissolving the contents of 1-2 sachets in 200 milliliters of water, 3 times a day. With intravenous administration, 4 ampoules are used per day, if necessary, the dose can be increased to 8 ampoules.
Side effects: abdominal pain, nausea, flatulence, vomiting, diarrhea, pain in the extremities, allergic manifestations.
Heptral( Heptor)
The active substance is ademethionine. The form of release - tablets, ampoules for injections.
It has detoxification, regenerating, antioxidant and antidepressant activity, it breaks fats and removes them from the liver, which is used for chronic hepatitis, toxic damage or cirrhosis of the liver, chronic acalculous cholecystitis, cholangitis, intrahepatic cholestasis of pregnant women, depression.
Take internally 800-1600 milligrams per day, intravenously or intramuscularly - 400-800 milligrams per day.
Adverse effects: abdominal pain, heartburn, indigestion, headache, weakness, sleep disturbance, hot flashes, chills, muscle cramps, allergic reactions.
Preparations of animal origin
for table of contents ^Hepatosan
Active substance - liver cells of donor pig. Form release - capsules.
Accepted for cirrhosis of the liver, hepatitis, hepatosis, liver failure, toxic liver damage, digestive disorders.
Depending on the severity of the disease appoint 1-2 capsules 2-3 times a day for 15-30 minutes before meals.
Side effects: allergic manifestations.
Progepar
Active ingredients - inositol, cyanocobalamin, liver extract of cattle N containing choline hydrotartrate, cysteine, cysteine hydrochloride. The form of release - tablets.
Used to improve blood flow in the hepatic tissue, restore the structure of hepatocytes, slow the formation of connective tissue in the liver, increase diuresis. Effective in the complex therapy of chronic hepatitis, with drug intoxication, cirrhosis, fatty liver, radiation sickness.
Take 1-2 tablets 3 times a day.
Side effects: allergic reactions.
Sirepard
The active ingredient is a liver extract extract hydrolyzate containing a standardized amount of cyanocobalamin. The form of release - ampoules for injections.
Has a pronounced detoxification effect, stimulates the regenerative processes of the liver parenchyma, prevents the development of fatty infiltration.
Adults and children from 15 years of age are prescribed 2-3 milliliters per day intravenously or intramuscularly, the course is 150-200 milliliters. Children 1-14 years - 1-3 ml per day for 2-6 weeks.
Side effects: pain in the abdomen, redness of the face, a feeling of heat, rashes on the skin, itching.