Doxium( Doxium) is a preparation with angioprotective and antiaggregatory action, which is used for diseases associated with impaired vascular wall permeability and microcirculatory disorders. The drug is manufactured by the pharmaceutical company OM Pharma from Switzerland.
The product is available in capsule form. Each capsule contains 500 mg of active substance - calcium dobesilate. In addition to it, the preparation contains auxiliary ingredients.
Contents
- Pharmacological properties and mechanism of action
- Indications and contraindications for use
- Dosage and dosage regimens
- Cases of overdose and "pobochki"
- Application of the drug in special cases
- Gross practical experience collected
- How to replace the rare drug?
Pharmacological properties and mechanism of action
Under the influence of calcium dobesilate on the capillary walls, their functions are regulated: increased permeability, reduced resistance and increased resistance.
Thanks to these processes, microcirculation and tissue nutrition with oxygen is improved. In addition, calcium dobesilate positively affects the state of lymphatic vessels, improving their drainage. Also, under its influence, platelet aggregation decreases, the elasticity of erythrocyte membranes increases and the viscosity of the blood decreases.
Calcium dobesilate formula
The action of the active component of the preparation is in some way achieved by reducing the activity of bradykinin and its direct effect on the vascular endothelium.
The drug also has antihemorrhagic action and eliminates edema.
The drug is slowly absorbed from the digestive tract. Its highest concentration in the blood is reached after 5-7 hours after administration.
Calcium dozesilate does not penetrate the blood-brain barrier. Removal of the drug in large part is provided by the kidneys.
Indications and contraindications for use
Doxium is used:
- for the treatment of chronic venous insufficiency, manifested by convulsions, soreness, sensory disorders,
swelling of the lower extremities; - in the complex treatment of superficial thrombophlebitis;
- with trophic ulcers;
- for the treatment of diabetic retinopathy;
- in postthrombophlebitic syndrome;
- as part of complex treatment of hemorrhoids;
- for the elimination of peripheral circulatory disorders;
- for varicose veins;
- in the therapy of hormone-dependent bronchial asthma.
Contraindications:
- hypersensitivity or allergy to any component of the drug;
- bleeding;
- gastric and duodenal ulcer;
- severe liver and kidney disease;
- age to 13 years;
- gestation period.
Dosage and Administration Schemes
The drug is used in a single dose of 500 mg( 1 capsule) 1-2 times a day during meals. Do not exceed the maximum daily dose, which is 1000 mg.
Duration of treatment and exact doses are set by the doctor individually, taking into account the severity and course of the disease, as well as the general condition of the patient and the presence of concomitant diseases.
The course of treatment can last from several weeks to several months.
Tips for the administration of medication:
- should be taken only as directed by a doctor;
- should carefully read the instructions for use before the start of treatment and store it throughout the therapy, it may be necessary to clarify with time;
- should be taken while eating or immediately following a meal, with plenty of water;
- can not chew or split capsules, you must swallow them whole.
Cases of overdose and "pobochki"
At the moment there is no information about an overdose with the drug. Doxium, when taken in the recommended doses, is well tolerated. Occasionally, there may be:
- allergic reactions in the form of a rash;
- indigestion;
- diarrhea;
- nausea;
- gastralgia;
- increase in hepatic enzymes.
Application of the drug in special cases
The drug does not affect the speed of mental reactions so it can be used to treat people whose work requires increased attention, as well as drivers of vehicles.
Despite the fact that there is no data on the interaction of the drug with alcohol, simultaneous reception is not recommended.
Features of application for violations of kidney and liver
Special care should be taken when using Doxium in patients with severe impairment of liver and kidneys.
It is forbidden to take the drug in the 1st trimester of pregnancy. Under the supervision of the doctor, taking into account all the risks for the fetus and benefits for the mother, 
can be used Doxium in the 2 nd and 3 rd trimesters of pregnancy.
Since some of the drug is excreted in milk, it is not recommended to use it during lactation. If there is a need for admission, then during the treatment should be abandoned breastfeeding.
There is no data on the safety of the drug in pediatrics, so it is not recommended to take the drug in childhood.
A bit of collected practical experience
Reviews of the drug is not so much. This is explained more by its long absence on the pharmaceutical market than by insufficient efficiency. Existing reviews still indicate positive changes when taking Doxium capsules.
The use of the drug for varicose veins helps to get rid of the symptoms accompanying this disease. In this case, it should be noted the excellent tolerability of the drug by patients.
Dmitry, phlebologist
Doxium is great for treating hemorrhoids. When he is admitted, there is a cessation of bleeding, as well as a reduction in the severity of other symptoms due to the restoration of normal blood circulation and nutrition of tissues.
Arkady, proctologist
I have chronic venous insufficiency. Receiving Doxium in several courses for 2 weeks a year helps me get rid of debilitating pain in my legs, numbness and swelling.
Antonina
This drug was prescribed to me by a doctor to combat varicose veins. Immediately the effect from its application was not very noticeable, but after drinking the whole course, I felt a noticeable relief.
Elena
Pros of the facility:
- high efficiency;
- has few contraindications;
- virtually no side effects.
Cons:
- rarely appears on the shelves of pharmacies.
How to replace a rare drug?
The drug should be stored in places inaccessible to children. The storage temperature should not exceed 25 degrees. Also need protection against direct sunlight. It is forbidden to apply the drug at the end of its expiration date.
This is a prescription drug, which means that its release should be carried out with a doctor's prescription.
At the moment there is no information on the price of Doxium, as the drug is not available in pharmacies, but on the drugstores you can find analogues of the drug: Dobesilat calcium, Etruval, Doxilek, Dobezifar and Doksy-chem.