The drug Trental improves the microcirculation of in areas of impaired blood supply, reduces blood clotting, increases the amount of oxygen produced by the myocardium, tones the respiratory muscles, increases the amount of cAMP in platelets, ATP in erythrocytes, dilates blood vessels, improves their elasticity, and dilutes blood.
Contents
- When is the drug used
- Form and price
- What can the drug differ from preparations with similar properties
- Best analogs
- Agapurin
- Pentylin
- Pentoxifylline
- Flexitale
- Vasonite
- Latren
- Which drug is better
- Video: Varicose veinsLevashov
When the
drug is used, Trental is applied:
- Raynaud's disease;
- impotence caused by blood flow disorders;
- pathology of the vessels of the inner ear( which leads to hearing loss);
- in case of transfer of myocardial infarction;
- peripheral blood flow disorders( lameness caused by diabetic angiopathy, endarteritis);
- disturbance of cellular nutrition of tissues( ulcers, frostbite, gangrene, varicose veins);
- circulatory disorders in KGM;
- ischemic heart disease;
- otosclerosis;
- circulatory disturbance in the retina or choroid of the eye;
- bronchial asthma;
- cerebral circulatory disorder caused by atherosclerosis;
- dyscirculatory encephalopathy;
- improper blood circulation in the inner ear, which causes hearing loss;
- emphysema.
Form and price
Basic forms release:
- trental 100 mg, tablets: from 250 to 480 rubles;
- trental 400 mg, tablets: from 395 to 490 rubles;
- trental, solution: on average, 150 rubles.
What can differ the drug from drugs with similar properties
Among the main characteristics of are:
- Price Trental is much higher in comparison with the drugs analogues.
- Concentration of active substance ( release form).
- Biological availability. Trental is assimilated by 90 - 93% - depending on the individual characteristics of the organism.
- Portability. Some patients experience side effects after taking Trental: dizziness, jumps, blood rashes, tachycardia, arrhythmia, nausea, angina progression, bleeding from the mucous membranes, impaired vision.
- Features of the application. Trental is prohibited during pregnancy and breastfeeding.
- Elimination half-life of the body .In Trental is 1 - 2 hours.
Active substance - pentoxifylline is a part of all drugs listed below.
The best analogues of
Modern medicine represents a number of Trental analogues in tablets and ampoules that also contain the active substance pentoxifylline , and have similar pharmacological properties.
Agapurin
is used to improve blood flow to the extremities of ( for patients with chronic occlusive lesion of the arteries of stage 2), with circulatory disturbance of the inner ear( sudden loss of hearing, deafness), for the prevention of thrombosis, rheumatism, bronchial asthma, lupus nephritis,
Bioavailability: 89 - 90%.
Product: tablet 100 mg, 400 mg, 600 mg, injection.
Not applicable during pregnancy and breastfeeding.
Side effects: identical to those described in the instructions of the drug Trental.
Half-life from the body: may be longer for half an hour( in comparison with Trental).
Price Agapurin:
- price, tablets, 100 mg: from 150 to 190 rubles;
- price, tablets, 400 mg: up to 280 rubles;
- price, tablets, 600 mg: up to 320 rubles;
- solution: 125 rubles.
Pentylin
Acute circulatory disturbance in KGM ( ischemic attack), peripheral arterial circulation problems( micro- and macrocirculation), Raynaud's syndrome, diabetic angiopathy, otosclerosis, erectile dysfunction,
Bioavailability: 90 - 93%.
Form release: tablets( 100 mg, 400 mg), concentrate for the solution.
The drug is prohibited during pregnancy and lactation.
Side effects are identical to Trental.
Half-life from the body: 1 - 2 hours.
Price of Pentylin:
- price, tablets 100 mg: 120 - 150 rubles;
- price, tablets 400 mg: 170 - 180 rubles;
- price, concentrate, ampoules: 82 - 95 rubles.
It should be noted that this drug is less common in pharmacies.
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Pentoxifylline
is used for peripheral circulatory disorders ( diabetic angiopathy, intermittent claudication, trophic ulcers of the leg), circulatory problems in KMG( atherosclerosis, ischemic lesions, vascular dementia), circulatory disorders in the retina, auditory and vestibular disorders associated with vascularsystem.
Bioavailability: 89 - 90%.
Product: tablet( 100 mg), concentrate for solution.
Not applicable during pregnancy and breastfeeding.
Side effects: In addition to what is indicated about the drug Trental, some patients may experience aseptic meningitis, tremor, paresthesia, hallucinations, cholestatic hepatitis, dry throat, thirst, conjunctivitis, lacrimation, ear pain, anemia, bleeding from the vesselsskin, toxic epidermal necrolysis, impaired taste perception, laryngitis, nasal congestion.
Half-life from the body: 1 - 2.5 hours.
Price Pentoxifylline
- price, tablets 100mg: 71 - 95 rubles *;
- price, concentrate for solution, ampoules: 33 - 35 rubles.
* the price is indicated for 60 pieces. Pentoxifylline is released mainly in such quantities.
* in the description of other drugs the price is indicated for 20 pcs.
Flexitale
is used in cases of peripheral ( endarteritis, Raynaud's disease, atherosclerosis) and cerebral( caused by arteriosclerosis of the vessels) circulation.
Also used for trophic tissue disorders( ulcers, frostbite), thrombosis, varicose veins, diabetic angiopathy, impaired blood circulation in the retina.
Bioavailability: 89 - 92%.
Product: tablet, 400 mg.
Intake during pregnancy and breastfeeding is only possible if absolutely necessary.
Side effects: similar to the drug pentoxifylline.
Half-time from the body: half an hour - an hour longer than Trental.
Price, tablets 400 mg: 250 rubles.
Vazonite
Improves blood microcirculation, reduces coagulation, dilates blood vessels, improves oxygen supply in areas of impaired blood circulation( namely, in the extremities, central nervous system, less in the kidneys), slightly widens coronary arteries.
Bioavailability: 93 - 94%( the highest rate of all described).
Product: tablets 600 mg.
Strictly contraindicated during pregnancy and breastfeeding.
Side effects: similar to Trental *.
Half-life from the body: 1,5 - 3 hours( due to increased concentration of active substance).
Price, tablets 600 mg: 280 - 340 rubles.
Latren
The drug is prescribed for diabetic neuropathy, peripheral circulation disorders, Raynaud's syndrome, tissue trophism disorder, obliterating dermatitis.
Also used in conjunction with other drugs for the treatment of varicose veins, post-thrombotic syndrome, gangrene, frostbite, trophic ulcers.
Suitable for normalization of circulatory function in the cerebral cortex. It effectively helps with atherosclerosis of cerebral vessels, discirculatory encephalopathy, ischemic stroke, circulatory failure in the eye( retina or choroid), vascular pathology of the inner ear( accompanied by hearing loss).
Bioavailability: 90 - 91%.
Product: solution for infusion, 100, 200, 400 ml.
The drug is not allowed during pregnancy and breastfeeding.
Side effects: besides those characteristic of Trental, leukopenia, thrombocytopenia, pancytopenia are possible.
Half-life from the body: 0.5 - 1.5 hours.
Price, solution for injection 200ml: 120 - 130 rubles.
Which drug is better
The basic active substance of each of the drugs is pentoxifylline , so the principle of action of the mentioned drugs is almost the same.
They differ, first of all, by the forms of release.
Pentoxifylline, the price of which is the most affordable, is only available in tablets of 100 mg.
With more aggressive treatment, this option will not be relevant. Also, this drug has several more side effects than other Trental 400 analogues in tablets.
Vazonite will be an ideal option for a sufficiently strong course of treatment, since one tablet of the drug contains 600 mg of active substance.
A similar trend in the selection of Trental analogues in solutions. Pentoxifylline is the most advantageous price solution. Further - Pentilin .
However, Latren has the widest spectrum of action of from the solutions presented.
In any case, all the presented drugs - analogs are a more advantageous price solution than Trental. Moreover, most of them have the same bioavailability to the body.
Video: Varicose veins along Levashov
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