The drug was created to suppress the spread of hormone-dependent tumor processes due to the action of progestogen microcrystals contained in it. In the course of the tests, it was found that the drug has a pronounced contraceptive effect, suppressing the function of endometrial enlargement and ovulation.
Depo-Provera preparation
The drug belongs to the group of gestagenic preparations. The composition contains the hormone medroxyprogesterone acetate. The activity of estrogenic and androgen hormones ceases, ovulation does not occur because follicles cease to ripen. The drug Depo-Provera( DMPA) inhibits the growth of the endometrium and affects the density of cervical mucus. Before treatment, the patient is examined and the risk of minimal complications caused by the gestagen-containing medication is assessed.
Application of Depot Provera
Indications for use of the remedy are:
- contraception;
- painful menstruation;
- endometrial hyperplasia;
- elimination of vasomotor manifestations at the onset of menopause;
- prophylaxis and treatment of endometriosis;
- relapses and metastases of kidney, breast and prostate cancer.
In cases where the injection is used as a contraceptive, doctors indicate its advantages over similar means:
- Suitable for women who contraindicated contraceptives containing estrogen.
- It is put 1 time for 3 months. A woman can forget about the daily intake of pills.
- Has a high level of protection against unwanted pregnancy.
- Reduces the risk of developing cancer.
Another area of application Depo-Provera is therapy of hormone-dependent tumors. For this, a different dosage of the progestogen is chosen. Depo-medroxyprogesterone acetate is used during recurrence of cancer and when metastases occur. It reduces the metabolism of corticosteroid hormones if higher doses of the drug are used.
Depo-Provera Instruction
The medicinal preparation has different uses, therefore it is available in different forms:
- syringe with medicine, intended for single administration - 150 mg in 1 ml;
- vial 1 ml containing 150 mg of active substance;
- vial 3.3 ml containing 500 mg of medroxyprogesterone.
According to the instructions of Depo-Provera for prevention of pregnancy, intramuscular injection is performed within 5 days from the beginning of a timely menstruation once every 3 months. Suspension should be thoroughly shaken, it has a thick consistency. When breastfeeding needs to be maintained, prescribing in lactating women is allowed, but the risk of complications for the baby is assessed because medroxyprogesterone is transmitted through milk. The number of courses should not be more than 3, then take a break for 6 months.
For treatment of other diseases the doctor individually determines the duration of treatment. Dosage is determined depending on the type of oncology:
- Endometrial and kidney cancer - 400-1000 mg once a week. After the improvement, the dose decreases.
- Breast cancer - 500-1000 mg / day for 4 weeks. Then begin to put 2 times a week for 500 mg.
- Metastasis of prostate cancer - 500 mg 2 times / week 3 months.
- Endometriosis - 50 mg per week, or 100 mg 1 time / 2 weeks for six months.
To remove unpleasant manifestations in menopause, injections should be given at 150 mg once every 12 weeks. Depo-Provera with endometrial hyperplasia is prescribed in the same dosage as with contraception. After the administration of the drug, care must be taken to ensure that a seal does not form at the injection site. The substance is absorbed into the blood gradually, with an allergic reaction and non-compliance with hygiene rules, inflammation may begin.
Side effects of Depo-Provera
Like many hormonal drugs, medroxyprogesterone not only helps treat severe illnesses, but also causes complications. If there is a malaise after taking the medication, you should immediately consult a doctor. The side effects of Depo-Prover include:
- disorders in the genitourinary system - irregular bloody discharge, menstrual disorder, anovulation, changes in the viscosity of the cervical mucus, breast engorgement;
- failure in the nervous system - drowsiness, dizziness, decreased concentration, convulsions, headaches;
- skin irritation - hives, itching, acne, allergic rash;
- development of diseases of the cardiovascular system - increased blood pressure, thrombophlebitis, heart failure, tachycardia, thromboembolism, myocardial infarction;
- disorders of the digestive system and liver - metabolic slowdown, weight gain, vomiting, loss of appetite, nausea, cholestatic jaundice, diarrhea;
- temperature increase;
- swelling on the legs.
Contraindications Depo-Provera
Before prescribing injections, doctors are advised to take tests for the content of progesterone in the blood and to undergo a checkup to exclude diseases in which the drug is forbidden to take. This will help to avoid serious side effects afterwards. Contraindications Depo-Provera:
- pregnancy and bleeding from the vagina of an unclear etiology;
- allergy to the hormones of the gestagenic group;
- liver disease;
- breast cancer( not suitable for contraception).
With great caution should be prescribed if available:
- epilepsy;
- for sickle-cell anemia;
- diabetes mellitus;
- chronic migraine;
- depressions;
Price for Depo-Provera
The medication is sold at the pharmacy under the prescription of a doctor, but if it is already prescribed, you can order and buy it from the online store by selecting from the photo from the catalog. The drug has an affordable price, the price for Depo-Provera depends on the form of release used to treat:
- syringe with a drug 1 ml, 150 mg - 150-170 rub;
- vial 1 ml, 150 mg - 110-160 rub;
- vial 3.3 ml, 500 mg - 180-215 rubles.
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Reviews
Julia, 40 years old
I started to stab, reading reviews on the Internet and consulting with a doctor. Not even the side effects frightened, but the inexpensive price pleased. At me all has passed normally, put 4 years with small breaks. The only problem that arose after injections was the cessation of menstruation. I had to take another medicine to restore them.
Helena, 27 years old
I'm writing a review so that women think about it before agreeing. I put it for the first time instead of tablets. After 3 days after the injection, she began to smear, almost like with menstruation. I went to the doctor, said - the hormonal background was broken, so it went on all the time until the action was over. No more for anything I agree to such torment!
Xenia, 56
I was prescribed this medicine 5 years ago, when the menopause came. Excess weight, as many write, I did not score, because he already had it. As for the other unpleasant manifestations, there was constant drowsiness, I did not want to do anything. But, as the doctor promised, the other symptoms of menopause did not bother me at all.