Reparil( Reparil) is an anti-inflammatory angioprotector made in Germany.
The main active substance of the medicine is the plant glycoside escin, which is obtained from the fruits of horse chestnut.
Refers to the pharmacological group of capillary stabilizing drugs that exhibit pronounced proteolytic activity.
Contents
- Pharmacological action
- Pharmacokinetics of the drug
- When and who needs the drug?
- Drug administration prohibited
- Mechanism of action
- Instruction for use
- Overdose and additional indications
- Side effects and special instructions
- Interaction with other drugs and with alcohol
- Pregnancy and lactation reception
- Features of the drug use by children
- From the practical experience of using
- Advice on admissionfrom patients
- Pros and cons judging by the reviews
- The cost of preparation
- Terms and storage terms
- Analogues of foreign and Russian products
Pharmacological action
Due to the high content of escin, the drug has a strong protective effect on the inner shell of the vessels.
Has also a pronounced anti-exudative effect, which manifests itself in a decrease in the permeability of the vascular wall, which, in turn, inhibits the release of fluid from the vessels into the tissues.
Reduces pain and helps to relieve swelling with varicose veins. The drug improves the overall microcirculation of blood, increases the resistance of small capillaries and inhibits the inflammatory processes of connective tissue.
In what cases will the best choice for varicocele will be Ivanissevich's surgery: technique and possible complications. Supplements for people suffering from various forms of venous insufficiency Doppelherz Venotonics - it is necessary to know before taking the drug.
Pharmacokinetics of the drug
The drug is rapidly absorbed into the bloodstream and evenly distributed along the vascular bed. The peak of action occurs 2 hours after application. Easily penetrates through the walls of organs and vessels.
The decay and elimination period is 48 to 80 hours. The body is excreted mainly with the help of kidneys.
When and who needs the drug?
Indications:
- varicose veins ( pathological changes in the vein wall, resulting in an uneven increase in their
lumen); - thrombophlebitis ( occlusion of veins, due to inflammatory processes of their internal membrane);
- phlebitis of superficial veins ;
- pain syndrome in diseases of the spinal column ( osteochondrosis, sciatica, pinching of intervertebral discs);
- disorders in the brain caused by swelling;
- concussion, concussion of the brain ;
- encephalitis ( inflammation of the membranes of the brain);
- damage to due to bumps, sprains, injuries.
Drug administration is prohibited.
Contraindications:
- hypersensitivity to escin;
- disorders in kidney function( kidney failure);
- rhesus-conflict during pregnancy( the mother has Rh-negative blood, and the fetus is Rh-positive).
Mechanism of action
The venotonic effect of the main component of escin is associated with its stimulating effect on the adrenal cortex. As a result, the release of hormones of adrenaline and noradrenaline, which act as neurotransmitters, bind to alpha-adrenoreceptors and lead to a narrowing of the lumen of the vessels.
Eszin is also known for its ability to eliminate venous congestion in varicose veins by alleviating the lymph flow and emptying the varicose veins.
The medication inhibits the synthesis of the enzyme hyaluronidase, which destroys hyaluronic acid, and it is responsible for maintaining the elasticity of the vein wall and controls the maintenance of the desired level of fluid in the tissues of the vessels.
The drug improves blood flow as a whole, greatly reduces the risk of blood clots and has antioxidant properties( renders free radicals in the blood).
Instruction for use
The drug is produced in the form of a powder for intravenous injection in ampoules of 5 mg, in the form of a gel for external use( Reparil-gel H) and in the form of pellets of 20, 50 or 100 pieces per pack( Reparil-40).
Adults with severe cases of thrombophlebitis and with violations of the brain are prescribed medication only intravenously 1-2 ampoules a day.
In the case of inflammation of the membranes of the brain or internal hemorrhage, one more ampoule per day can be additionally stained, but the daily dose should never exceed 20 mg.
For children from 1 to 3 years old The spray was injected intravenously at a rate of 0.1 mg / kg of body weight per day. Children aged 3 to 12 years, the dose can be doubled 0.2 mg / kg body weight.
Patients with varicose veins, which may be accompanied by phlebitis or a violation in the operation of the valvular apparatus of the veins, prescribe a drug in the form of a dragee and gel.
A course of treatment begins with taking 1 tablet after meals 3 times a day, after a while, if there is an improvement, the dose can be reduced to 2 pills a day.
Reparil-gel N can be used for adults and children from 12 years. A thin layer of gel should be applied to the affected areas several times a day, while avoiding its strong rubbing into the skin.
Overdosage and additional indications
When taking medication in the form of a dragee or intravenously dose of more than 20 mg per day, symptoms of an escin overdose are observed: elevated body temperature, nausea, possibly vomiting.
About cases of overdose Reparil-gel H was not previously reported.
Side effects and special instructions
Heat, nausea, allergic reactions of delayed type( rash on the skin, urticaria), angioedema may occur, in rare cases - anaphylactic shock( allergic reaction of immediate type).
Before starting treatment, it is necessary to consult with your doctor. If one or more side effects are found during the reception of the remedy, it is necessary to stop the therapy and consult a doctor again.
Interaction with other drugs and with alcohol
The active substance escin enhances the effect of anticoagulants( anticoagulants).
Other interactions with drugs and alcohol have not been detected.
It is forbidden to take medicine in any form if there are abnormalities in the functioning of the kidney apparatus, accompanied by kidney failure.
In case of abnormal liver function, medication is possible, but only after consultation with the attending physician.
Pregnancy and lactation reception
During pregnancy and lactation, the drug should be taken only after medical consultation. In the case of using a medicine in the form of a gel, it is necessary to avoid applying to the area of the mammary glands.
Features of the drug for children
Reparil-gel N is not recommended for children under 12 years of age.
Dragee and powder for injection can be administered if necessary to children from 1 year. Dosage should be in accordance with the instructions for the drug.
From the practical experience of using
You will find reviews of doctors and patients about the drug Reparil below.
For more than one year I have been appointing patients with varicose veins to Reparil. Since it contains only natural components, it does not cause side effects.
The result is also happy. Basically, I prefer gel form, intravenously I prescribe only in severe cases of thrombophlebitis.
Lyudmila, phlebologist
Reparil is for me a sample of the ratio of acceptable price and high quality.
recommended it not only to patients with varicose veins and its complications, but also to those who undergo rehabilitation after operations associated with abnormalities in the vascular valve system. Remained very pleased with the results.
Sergey, vascular surgeon
I have been suffering from varicose veins for many years, just like my mother. Tried many different ointments and all kinds of gels. The doctor advised Reparil-gel.
I will not say of course that the pain was gone at all, but I felt really much easier. I have not found anything better yet.
Katya, 40 years old
Varicose veins for a long time, and two years ago phlebitis of superficial veins joined. It was excruciated strongly, could not go. Assigned Reparil intravenously.
The effect came already after two weeks, really felt relieved. Now from time to time I use Reparil-gel. Acts not as much as injections, but it also helps.
Elena, 52 years old
The drug is normal, German all the same, but the price is too expensive for me. A year ago he still bought, but now he has risen in price. I'm looking for a Russian analogue cheaper.
Dmitry, 49 years
Tips for receiving from patients
I have varicose veins, diagnosed 5 years ago. Now half a year I use Reparil-gel N.
I advise to not put or render it or him for the night as to rub a gel it is impossible, for the morning there are traces on a bed-sheet. I usually apply when I come home from work and still have a couple of hours to sleep.
Hope, 45 years old
I have thrombophlebitis of the lower extremities. Despite the young age I have been ill for a long time, it's my hereditary. One doctor advised to pierce Reparil, said that the drug is German, good.
Has passed or has taken place a course of treatment, pricked in 3 ampoules a day daily. I did not feel very much, I felt sick all the time, fever and dizziness. The effect, of course, was manifested, the legs stopped being so sick, it became easier to walk. But I recommend starting to stab 2 ampoules a day, and not immediately as much as I do.
Vladimir, 42 years
Pros and cons judging by reviews of
Pros: 
- is a natural harmless medicine;
- is safe even for children;
- virtually no side effects and contraindications;
- effect comes in a few days of use.
Cons:
- causes allergic reactions in patients with hypersensitivity to escin;
- high price.
The cost of the preparation
Forms and price in rubles
- Reparil-gel N - 153 rubles;
- dragee 100 pieces per pack - 4100 rubles;
- powder for injection - 55 rubles per ampoule.
Storage conditions and storage conditions
Store at temperatures below 25 ° C in a dry place inaccessible to children. Shelf life is indicated on the package and is different for different forms of release.
Available without a prescription.
Analogues of foreign and Russian production
Foreign analogs Reparila:
- Venen Theiss( Germany);
- Venoplant( Germany);
- Venosmil( Spain).
Russian analogues:
- Aescin;
- Eszin;
- Escuzan.