The importance of timely proper treatment of cardiac diseases can not be overemphasized. To help doctors and patients in this process, the pharmacological industry provides a wide range of drugs for the therapy of heart disease. Read the information on what indications cardiologists appoint Coraxan - the instruction for the use of these tablets gives detailed information about the list of ailments in which this drug is shown, and also what side effects may appear when taking it.
What is Koraxan
According to the medicines registry( RF) of the Russian Federation, the drug Coraxan is the trade name of tablets produced by the French company-manufacturer Servier. This medicine belongs to anti-anginal remedies and is successfully used to treat angina pectoris( in Latin the name of this disease sounds like angina pectoris, hence the name of the group of drugs).Coraxan tablets slow down the rhythm of the heart, reducing the heart rate( heart rate).
The peculiarity of this drug is that it regulates the heart rate dose-dependent and affects only the if-channels of the sinus node, without affecting the contractility of the myocardium, intracardiac conduction and repolarization of the ventricles of the heart.
Thanks to such properties, in cardiological practice, doctors can prescribe Coraxan without fear that it will affect blood pressure or myocardial contractility, or provoke angiospasm .Composition and Form of Release
The main active ingredient of Coraxan is ivabradine( in the form of ivabradine hydrochloride).In the pharmacy network, this drug is presented in coated tablets. Depending on the dosage of ivabradine, the drug Koraxan 5 mg and 7.5 mg are distinguished. The number and list of excipients for both forms of release is the same - tablets and their shell contain:
- lactose monohydrate;
- maltodextrin;
- cornstarch;
- magnesium stearate;
- silica;
- titanium dioxide;
- hypromellose;
- macrogol 6000;
- dyes from iron oxide.
Indications for use
Cardiologists prescribe Koraxan as an effective therapeutic agent in the following conditions:
- of stable angina( if a patient is contraindicated with drugs from the β-blocker group or receiving such drugs is not sufficient to monitor the patient's condition);
- of chronic heart failure( if sinus rhythm is observed and HR is maintained at least 70 beats per minute);
- ischemic heart disease( for normalizing the rhythm of the myocardium).
Instruction of Koraxan
The daily dosage prescribed by the doctor is divided into two methods - morning and evening. If a single dose of ivabradine is prescribed 2.5 mg, only Koraxan 5 mg tablets can be divided into equal doses. Take medicine should be at the same time as eating - so its effect increases several times. Important: for the period of treatment from the patient's diet, grapefruit juice must be excluded! This drink doubles the concentration of ivabradine in blood plasma. For the same reason, combined use of Coraxan and perforated St. John's wort should be avoided.
With angina
With such a disease, the initial daily dose of the drug is 10 mg and, depending on the result of therapy, can be increased 3-4 weeks to 15 mg. To the patient with angina pectoris, which accepts Coraxan, it is necessary to watch that the heart rate does not fall below 50 beats per minute. When this level is reached, or if the patient has a bradycardia( low blood pressure, severe fatigue, dizziness), the dosage of the drug should be reduced or even stopped taking the tablets.
With heart failure
With such indications, Coraxan can be prescribed only if the patient has a stable course of the disease. The initial dose is often also 10 mg per day. After two weeks, the dosage can be increased to 15 mg / day( if the heart rate in a person at rest is more than 60 beats per minute) or reduced to 5 mg / day( if less than 50 beats per minute are recorded). In cases where the heart rate persists below 50 bpm.or if there are persistent symptoms of bradycardia, taking Koraxan should stop the .
Analogs
People who consider the price of this drug high are often interested in cheaper substitutes for this drug. As an analog of Koraksan on the therapeutic effect in the therapy of angina pectoris, such drugs are used:
- Altiazem PP;
- Asparagus;
- Amlodipine;
- Betalk;
- Validol;
- Hypoxen;
- Isoket;
- Concor;
- Carvedilol;
- Cordypin;
- Metocard;
- Monolong;
- Nitroglycerin;
- Normodipine;
- Papaverine;
- Prestan;
- Sustonite;
- Efox Long , etc.
Contraindications
According to the instructions for use, the medication of Koraxan and certain medications: macrolide antibiotics, antifungal drugs of the azole group, HIV protease inhibitors and nefazodone is not allowed when prescribing the tablets. This anti-anginal remedy can not be used in pregnancy, with breastfeeding and for children. Contraindicated Koraksan and with such diseases and human conditions:
- severe arterial hypotension( at arterial pressure below 50/90 mm Hg);
- unstable angina;
- acute myocardial infarction;
- cardiogenic shock;
- immediately after a stroke;
- moderate to severe hepatic insufficiency;
- of renal failure;
- heart rate is less than 60 beats per minute;
- availability of an artificial pacemaker;
- pigmentary degeneration of the retina.
Side effects of
This undesirable effect of the drug on the human body occurs if the Coraxan dosage is incorrectly selected and the increased concentration of ivabradine is observed in the bloodstream. In such situations, the patient may experience:
- a change in color perception after a rapid change in the brightness of the lighting;
- bradycardia;
- atrial fibrillation;
- atrioventricular blockade( sharp slowing of the heart to 20-40 beats per minute);
- syndrome of acquired weakness of the sinus node;
- severe headaches;
- increased fatigue;
- diarrhea;
- constipation;
- allergic reactions.
Price for Koraxan
Among people who, according to the appointment of a cardiologist, use such a medicine, there is no consensus on whether such a medicine is expensive or cheap. Each buyer evaluates this aspect, based on their financial capabilities. On average, the cost of Koraksan in pharmacies in Moscow is 1125-1200 rubles for 56 tablets of 5 mg or 1145-1260 rubles for 56 tablets of 7.5 mg. It should be noted that the price of the drug will be slightly different depending on where the purchase is made: in a stationary pharmacy or through an online store with delivery.
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Reviews of cardiologists
Discussing the practice of using Coraxan, experts note the pronounced therapeutic effect of these tablets. The instructions to the drug detail the mechanism of pharmacodynamics and pharmacokinetics of the drug, provide detailed information on the compatibility of such a drug with other medicines, which allows the best way to include the drug in the treatment of the patient. According to the opinion of cardiologists, the majority of patients tolerate therapy with Coraxan well, withdrawal of treatment due to side effects occurs very rarely - about 1% of cases.
Reviews
Евгения, 47 years
For me, the use of Coraxan has become synonymous with the concept of "good health".Previously, I was very afraid of attacks of sudden heartbeats, but after taking these pills I realized that you can help yourself very quickly. Such a tool after a detailed examination was chosen by a cardiologist, so I'm sure that in my medicine cabinet is the best help for my heart.
Valentina, 54 years old
It's good that Coraxan has such detailed instructions for use! I, though I trust my cardiologist, have nevertheless studied this manual. During the treatment, I had attacks of very fast heartbeats, and according to the instructions, with arrhythmia, Koraxan pills are ineffective. I reported this to the doctor, and the treatment was timely adjusted.
Marina, 44 years
I liked the soft effect of tablets on the body and that they do not affect the pressure( it's already low in me).However, there is a problem to buy Koraksan in our small town - not everywhere you can easily find it in pharmacies. Well, that there is a sale of drugs by mail, it really helps. Means, although expensive, but I'm very satisfied with its effect.
Tatiana, 42 years old
My mother, after a visit to the doctor, ordered me to buy this medicine, because she also did not find a remedy in her town. Quickly sent her pills - in St. Petersburg they are not a problem to find. However, now my mother is going to the doctor again, because there are side-shots in sight - says that such effects before your eyes happen, as after a decent dose of alcohol.