For the removal of itching and irritation with onychomycosis, candidiasis and other diseases of skin fungal diseases Terbinafine is prescribed - the instruction for the use of the preparation contains information about its composition, indications and dosage. The product has a fungicidal action, and for convenience is available in several forms for local or internal use. Regardless of it, terbinafine displays a wide range of antifungal activity against almost all fungal cells that affect the human body.
Terbinafine - from which the
helps. According to the instructions, the drug belongs to the category of antifungal. In low concentrations, its use has a fungicidal effect, which helps to get rid of dermatophytes, dimorphic and mold fungus. The effect of the drug is to destroy the membrane of the pathogen of the fungal disease. This action of terbinafine has found application for the treatment of skin mycoses, nail lesions with fungus, trichophytosis, epidermophytosis, microsporia and thrush.
Composition and Form of Release
The preparation is available in several forms, the main active ingredient of which is terbinafine hydrochloride. In addition to the active component, the composition also includes auxiliary ones. They differ for each form of release:
| Form | Amount of terbinafine hydrochloride | Excipients |
| Ointment | 10 mg in 1 ml( 1%) | cetostearyl alcohol; poloxamer; benzyl alcohol; dimethicone; cetomacrogol 1000; paraffin; glyceryl; purified water; Propylene Glycol. |
| Cream | 10 mg in 1 ml( 1%) | sodium hydroxide; sorbitan monostearate; cetyl palmitate; Tween 60; cetyl alcohol;isopropyl myristate; benzyl alcohol; purified water. |
| Tablets | 250 mg | of croscarmellose sodium; calcium stearate; cellulose; of giprolose; lactose monohydrate; silicon dioxide. |
| Spray | 10 mg in 1 ml | ethyl alcohol; macrogol 400; purified water; Propylene Glycol |
Pharmacodynamics and Pharmacokinetics
Terbinafine - instructions for use, the drug treats it as an antifungal. The drug is effective against pathogens of fungal type - mold, dimorph and yeast fungi. To the latter, a fungistatic action is also manifested. The active component of the drug stops the production of ergosterol. Due to the lack of this substance, all the enzyme systems of the exciter cell are inactivated, the biosynthesis of sterols in it is suppressed, resulting in death of the fungus. Pharmacokinetics of the drug:
- With oral therapy, the active ingredient is rapidly absorbed, followed by partial metabolism in the liver, as a result of which the bioavailability of the drug is reduced to 40%.With topical application, absorption through the layers of the skin is only 5%.
- The highest concentration of terbinafine in plasma is observed 2 hours after administration. A greater amount accumulates in the skin integuments, nails, hair. Terbinafine penetrates and subcutaneous fatty tissue.
- In the body, the drug is transformed into metabolites that are excreted in the urine. The half-life is 17 hours. In people who have problems with the liver or kidneys, the medicine circulates longer in the blood because of the lowered terbinafine clearance.
Indications for use
For various fungal diseases Terbinafine is used - the instruction for its use as a general indication indicates diseases caused by mold or yeast infection or dermatophytes. The purpose does not depend on the form of release of the medicine. Tablets, cream or ointment are used to treat diseases caused by Candida fungus, dermatophytes of the genus Epidermophyton floccosum, Microsporum canis, Trichophyton. Such pathologies include candidiasis, microsporia, trichophytosis, epidermophytia, onychomycosis. Cream and ointment is used in case of colored lichen.
How to use and dosage
According to the instructions for use, depending on the form of release Terbinafine is used externally or taken internally. The method and duration of treatment are determined by the specific disease. Their correction is handled by a doctor, taking into account the severity of the ailment. The amount of the drug also varies for adults and children. In the latter, when taking a single dose, weight is also taken into account.
Ointment Terbinafine
According to the instructions, the product lubricates peeled and dried skin 1-2 times throughout the day. Apply a thin layer of ointment on the affected area and a small area adjacent to it. It is better to rub the drug until completely absorbed. If there is intertrigo after applying ointment on the lesion of the skin, you need to put a piece of gauze, especially at bedtime. The course of treatment is determined by the disease:
- dermatomycosis of the feet - 2-4 weeks;
- candidiasis of the skin - 1-2 weeks;
- multi-colored lichen - 2 weeks;
- mycosis of the nail plate - 3-6 months.
Spray
According to the instructions spray is applied by pressing the nozzle-sprayer. It is necessary to squeeze out an amount that is enough to moisten the affected area. Additionally, the product is sprayed onto adjacent healthy areas. The duration of treatment is:
- 2 weeks - for multi-colored lichen;
- 1 week - for shin or torso dermatomycosis;
- 1 week - for dermatomycosis stop.
Cream Terbinafine
Used similarly to ointments, too, on washed and dried skin. The cream is applied to the affected areas 1-2 times throughout the day, slightly rubbing the product. If the fungal infection of the skin is accompanied by an intertrigo between the buttocks, under the mammary glands, between the fingers or in the groin area, these places are covered with gauze. The average duration of treatment is:
- 2 weeks - for multi-colored lichen;
- 1-2 weeks - for skin candidiasis;
- 1 week - for shin or torso dermatomycosis.
Tablets Terbinafine
The duration of oral intake of tablets is determined by skin disease, and children should better consume them after eating. A single dose for a child is calculated taking into account its weight%
- 62.5 mg - with a body weight of less than 20 kg;
- 125 mg - with a weight of 20-40 kg;
- 250 mg - with a mass exceeding 40 kg.
For adults, tablets are administered in an amount of 250 mg. According to the instructions, the dose can be divided into 2 doses. Terbinafine with thrush skin, dermatomycosis of the trunk, legs or extremities are taken for 2-4 weeks. Duration of treatment for other diseases:
- 4 weeks - with skin infections of the scalp;
- 2-6 weeks - in case of dermatomycosis stop;
- 6-12 weeks - with onychomycosis.
Special instructions
If treatment of onychomycosis lasts more than 6 weeks, removal of the nail-affected nails is not required. The duration of the course is affected by the presence of concomitant systemic diseases. According to the instruction, the risk of recurrence and exacerbation is high with premature termination or irregular use of the medication. Very rarely after 3 months of treatment, hepatitis and cholestasis occur. The medicine is canceled when there are symptoms of liver disease.
Drug Interaction
According to the instructions for use, while taking medication with ethanol or drugs that have a hepatotoxic effect, the risk of drug damage to the liver increases. In women, when taking oral contraceptives, the menstrual cycle may be impaired. Interaction of the drug with other agents:
- increases the concentration of H2-histaminoblockers in the blood;
- slows the excretion of Rifampicin;
- preparations inhibiting microsomal enzymes of the liver inhibit the terbinafine clearance;
- has no effect on Digoxin, phenazone, Warfarin;
- inhibits the metabolism of tricyclic antidepressants, antipsychotics, beta-blockers;
- has an effect on the clearance of drugs in the metabolism of which the cytochrome P450-Cyclosporine system, oral contraceptives, Tolbutamide is involved.
Side effects of
According to the instructions, with local use of Terbinafine, some patients experience burning, itching and hyperemia in the area of application of cream or ointment. Allergic reactions are very rare. Based on the reviews of patients, the following side effects can be observed from Terbinafine tablets:
- appetite impairment;
- taste disorder;
- allergy;
- diarrhea;
- nausea;
- sensation of weakness and pain in the epigastric region;
- cholestasis.
Overdose of
If the dosage of tablets mentioned above is exceeded, the patient may experience nausea, headache, vomiting and dizziness. Against this background there is abdominal pain, frequent urination and rash. If the ointment or cream was accidentally taken orally, then the following symptoms appear:
- headache;
- pain in epigastrium;
- nausea;
- dizziness.
Contraindications
The instructions for use indicate that patients with chronic lesions of chronic terbinafine tablets should be administered with caution. The same applies to patients with:
- hemopoiesis;
- narrowing of the vessels of the limbs;
- alcoholism;
- tumors;
- with psoriasis;
- systemic and cutaneous lupus erythematosus;
- endocrine diseases.
Instructions Terbinafine in the form of ointments and creams is not allowed for use in case of hypersensitivity to the components of the drug or the appearance of allergies after its application. Absolute drug contraindications include:
- lactose intolerance;
- deficiency of lactase;
- is glucosogalactosal malabsorption;
- lactation period( the drug is excreted together with milk);
- pregnancy( studies of the effect of the drug on the fetus were not conducted);
- acute or chronic kidney and liver disease;
- age is up to 3 years and weight is up to 20 kg.
Terms of Sale and Storage
The recipe is required only for the purchase of terbinafine in the form of tablets, ointment and cream can be purchased without prescribing a doctor. Shelf life of the product is 2 years. According to the instructions, it is necessary to store the medicine at a temperature below 25 degrees and in a place inaccessible to children.
Terbinafine - analogues of
Analogues of terbinafine include preparations with the most similar composition or principle of action. Among these drugs are the following:
- Lamikan;
- Exifin;
- Myconorm;
- Terbisyl;
- Onyxon;
- Binafine;
- Lamizil Uno;
- Thermic;
- Terbinox.
Price of Terbinafine
The drug may cost differently depending on the place of purchase. You can buy it in a regular or online pharmacy at the prices shown in the table:
| Place of purchase | Form | Volume, amount | Price, rubles |
| Eurofarm | Ointment 1% | 15 g | 65 |
| Cream 1% | 15 g | 80 | |
| Cream 1% | 30 g | 150 | |
| Tablets | 14 pieces | 245 | |
| ZdravZona | Cream 1% | 15g | 65 |
| Cream 1% | 30 g | 141 | |
| Tablets | 28 pieces | 641 | |
| Tablets | 14 pieces | 195 | |
| Spray 1% | 20 ml | 152 | |
| Pharmacy IFK | Terbinafine Ointment from the fungus 1% | 15 g | 79 |
| Cream 1% | 30 g | 191 | |
| Tablets | 30 pieces | 620 |
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Reviews
Alina, 28 years old
Do not spend too much money on prsParaty Terbinafine copes with the fungus, it has good reviews. After visiting the pool I had mycosis on the big toe, but the drug quickly eliminated the problem. In addition, I took pills, so there was no recurrence of the infection. Now I always keep this medicine in the medicine cabinet just in case.
Julia, 32 years old
A kitty was picked up from the street, and two weeks later the child became ill. After visiting the doctor began to lubricate his appointment with terbinafine cream. The effect of the drug really was. The cream remained, and we tried to treat the fungal nail damage of the husband. The result was a week later. The fungus did not pass to healthy nails.
Olga, 41 year
From a fungus on the big toe, they prescribed this medicine in the form of tablets. On the first day of admission, the head began to hurt. Day passed, this side effect passed, but then reappeared, so the tablets had to be abandoned. I switched to an ointment, there were no more negative reactions, and the fungus passed for 2 weeks.
Andrey, 52 years old
The hands were affected by a fungus of 8 nails. He took one tablet of terbinafine for 3 weeks. The state of the nails began to improve only after 1.5 weeks. A month later I repeated the course of treatment. Of the minuses, noted only a frequent headache, but over time, it began to manifest less so, so I did not notice it.