The existence of endometrial tissue in the muscular layer of the uterus is pathological. This disease is called adenomyosis. It leads to abdominal pain, severe changes in menstrual function, and reproductive disorders. The quality of life is reduced, and the progression of the disease leads to dangerous consequences. In each case, with the diagnosis of "adenomyosis of the uterus" treatment, the drugs are selected individually. After all, the disease occurs at different ages, and its causes are also not the same.
What will help cope with adenomyosis
the smooth functioning of the reproductive system occurs at a certain balance of sexhormones. Disturbances in this area lead to various malfunctions, one of which is the percolation of the cells of the uterine mucosa into the next layer of the organ - myometrium.
The most common type of hormonal disorder is the predominance of estrogens. Normally, they allow the necessary development of the endometrium. But their excess leads to the fact that the cells of the mucous are divided too intensively. Therefore, with a disease such as adenomyosis, treatment with hormones that suppress estrogen activity, is one of the methods for solving the problem. The correctness of the development of the mucosa is restored, the pathological foci in the myometrium are reduced, and the state of health improves.
Drugs providing balance in the hormonal sphere, can give a fairly lasting effect. There are several of their groups that reduce the level of estrogens in different ways.
Since adenomyosis gives a pronounced pain syndrome, treatment is supplemented with the drugs that remove it. It can be Analginum, Papaverin, spasmolytic No-Shpa. A similar action with anti-inflammatory effect will have Ibuprofen.
Oral contraceptives
Combined oral contraceptives are prescribed not only for the sake of preventing pregnancy. Those of them that contain small doses of estradiol and a derivative of progesterone, equalize the natural balance of hormones in the body.
Normalizing the functions of the ovaries, that is, the formation of germ cells, and therefore the natural level of estrogens and the development of the endometrium, COCs provide:
- Reduction of pain and discharge during menstruation;
- Termination of uterine bleeding and ointments on other days;
- Preventing delays.
The effect will be noticeable after a continuous 3-6-month reception. After completing the use of the packing of tablets, the next day you need to start a new one. For the treatment of early adenomyosis, specialists choose:
- Jeanine;
- Log;
- Marvelon;
- Jess;
- to Yarin.
Antigonadotropins
This type of drugs interfere with the release of pituitary hormones, due to which there is a decrease in the efficiency of the ovaries and there is no provocative effect on endometrial tissue. Those who are worried about the adenomyosis of the uterus are prescribed treatment, using drugs:
- Danazol. Take 400-800 mg per day, guided by the prescription of a doctor. Begin use from the beginning of the cycle. The drug at the time of administration reduces the amount of menstrual flow or causes amenorrhea;
- Danol. Treatment scheme is similar to Danazol.
In addition to amenorrhea with prolonged admission, hair loss, the appearance of acne, headaches, malfunction of the menstrual cycle, as the drugs have an androgen-like effect.
Progestogens
With a high concentration of estrogens, progesterone is able to cope. It inhibits and stops the proliferation of endometrial tissue, and hence, the foci of adenomyosis. Artificially synthesized progestins are contained in the preparations:
- Dufaston( dydrogesterone);
- Norcolut( norethisterone).
Feature of them is the lack of influence on the work of the ovaries. The drugs support the luteal part of the menstrual cycle, that is, they do not allow the endometrial cells to multiply excessively. Their influence extends to tissues similar to the mucous uterus located in the muscle layer. The effect of admission will become apparent on:
- Decrease in the volume of menstrual flow;
- Stabilization cycle;
- Reduces pain during critical days.
Monthly for Dufaston and Norkolut do not disappear. The time of use of the drug depends on them. Tablets are drunk from 5 or 16 to 25 days of the cycle, 2 pieces per day. Exactly the period of admission will appoint a doctor.
Antiestrogens
There are synthetic substances that affect the production of not only estrogens, but also components released by the pituitary gland, and gestagens. All these hormones in adenomyosis of the uterus are reduced:
- Gestrinone. Its active substance belongs to steroids, it inhibits the production of sex and gonadotropic hormones. Thus, the mucosal cells lose their nutrition, atrophy. This leads to an end on the background of taking gestrinona monthly, abdominal pain, other bleeding. Begin to drink the drug in the 1st, after the 4th day of the cycle for 1 capsule. Then the same amount is taken twice a week for a period of six months;
- Depo-Provera( medroxyprogesterone).As a result of taking the drug, the egg does not mature and decay, that is, the sex hormones cease to support the development of the tissues of the uterine mucosa. They atrophy in the thickness of the body, which stops the pain, menstruation, bloody discharge from the vagina. Depo-Provera in adenomyosis is injected intramuscularly once a week for 50 mg or 100 mg every 14 days. The course is 3-6 months.
Analogues of Gonadoliberin
Gonadoliberin is a substance that enhances the production of FSH and LH.Its excess in the body first stimulates the functions of the sex glands, and then sharply reduces their work to zero. To achieve this, the following drugs with adenomyosis can be used:
- Buserelin( tryptotrelin).To achieve the "turn-off" effect of the ovaries, the solution is injected intramuscularly at 4.2 mg every 28 days, starting treatment with a 5-day cycle;
- Goserelin, Zoladex. Injections of one of the drugs are made subcutaneously at 3.6 mg every 4 weeks;
- Decapeptil Depot( Tryptotrelin).The agent is injected into the muscle at 3.75 mg every 30 days.
Treatment with gonadoliberin can be accompanied by a deterioration in general well-being, that is, tides, neurosis, palpitation, sweating. Menstruation on their background does not come.
We recommend reading the article about the possibility of pregnancy with adenomyosis. You will learn about the probability of conception, methods of treating the disease, problems with bearing a child with adenomyosis.
Antiandrogens
The effect in the fight against adenomyosis is given by the drug Byzanne. Its basis is dienogest, which is a derivative of nortestosterone. Byzanne has a strong influence on the body. As a result of its intake, the level of progesterone significantly increases and the volume of estrogen decreases, due to which fading of adenomycosis foci occurs. Byzantine in the form of tablets drink 1 piece per day for at least six months. At reception probably disappearance monthly.
Adenomyosis of the uterus is a serious problem, treatment, especially hormonal drugs, should be prescribed after a detailed examination. Many of these drugs have contraindications, some are unacceptable in pregnancy and feeding.