Nasal preparation in the form of an aerosol is used for diseases of the nasal cavity. Spray Tafen Nazal, whose main active ingredient is budesonide, belongs to the category of corticosteroid drugs of local action, normalizing the respiratory function. This therapeutic effect is provided by anti-inflammatory, anti-allergic action. The drug is able to reduce the severity of symptoms of allergic rhinitis and other diseases of the nasal cavity.
Tafen Nazal - instructions for use
The drug is intended for nasal use, it is important to follow the dosage specified in the manual( or the doctor-adjusted dosage).To treat adults, 2 doses of 50 micrograms are administered twice daily to each nostril. With a supporting therapeutic course, a minimum dosage is used that can cope with allergic rhinitis. Proper, regular use of the medication helps to achieve a complete therapeutic effect, while reducing the severity of the symptoms.
Composition of
One dose of the nasal preparation contains 50 μg of budesonide, the active active ingredient. In addition, the structure of Tafen Nazal includes such substances:
- simitikon-emulsion;
- propylene glycol;
- microcrystalline cellulose;
- disodium salt;
- purified water.
Form
The drug is a nasal spray and is available in small vials of dark glass with a dispensing device( spray) and a special nozzle for the nose. The drug in the form of a spray contains about 200 doses.
Pharmacodynamics and pharmacokinetics
Tafen Nasal drops represent a glucocorticoid drug for intranasal administration and are a first-line drug in the treatment of allergic rhinitis. The pharmacological action of budesonide is aimed at removing the inflammatory response in the upper respiratory tract and alleviating the common cold. In this case, the spray for the nose is not inferior in efficiency to systemic glucocorticosteroids, which are taken internally. Advantage of Tafen Nazal is that side effects with topical application of the drug are extremely rare.
Budkesonide in drops consists of synthetic glucocorticoids with pronounced anti-inflammatory, immunosuppressive, antiexudative and antiproliferative action. When using the drug on the mucous tissues of the nose, the components of Tafen Nazal practically do not enter the systemic circulation. The spray reduces inflammation due to the action of arachidonic acid, which inhibits the formation of mediators of the pathological process.
Drops act as an inhibitor of the release of bioactive substances that stimulate the development and course of the inflammatory reaction. In addition, the drug provides vasoconstrictor action( narrows the vessels in the nasal cavity, eliminating puffiness).The glucocorticoid effect of the drug is supplemented by its insignificant mineralocorticoid effect. As a rule, if the therapeutic dose is observed, Tafen Nazal makes the signs of allergic inflammation easier 2-3 days after the start of treatment.
With intranasal application of the drug, about 20% of the active substance enters the systemic circulation, while the bioavailability of budesonide is very small: at least 90% of the component in the blood is deactivated by the liver. Spray substances are distributed in the tissues of the body and bind to plasma proteins. The activity of glucocorticoids in the form of the main metabolic products is less than 1% of the activity of the main component of the preparation. The products of metabolism are removed mainly through the urinary system.
Indications for use
Nasal spray is used for preventive and therapeutic purposes. So, Tafen Nazal is applied for:
- treatment of polyps of the nose;
- prevention and therapy of allergic rhinitis;
- sinusitis;
- treatment of non-allergic rhinitis.
Contraindications
Before using the drug, the patient should carefully read the instructions, since nasal drops have a number of contraindications. The following contraindications are prohibited for their use:
- active form of pulmonary tuberculosis;
- increased individual sensitivity to the components of the drug;
- fungal, viral and bacterial pathologies of the upper respiratory tract;
- breastfeeding, pregnancy.
Method of administration and dosage
The drug is used for injection into the nasal cavity. For an adult and a child over 6 years of age, a nasal spray is prescribed in a daily dose of 400 micrograms. Typically, the drug is administered according to this scheme: 2 injections in each nasal pass twice per day. With maintenance therapy, Tafen Nazal, patients are prescribed 200 μg per day. The maximum allowable duration of use of drops is 12 weeks. As a rule, the effectiveness of treatment manifests itself in a few days after the application of the spray.
If the injection of the drug has been missed, the remedy is used in the near future, but not later than one hour before the next dose. The therapy is stopped with drops slowly, gradually reducing the dosage of the nasal agent. If you use Tafen Nazal according to the instructions, the risk of side effects is minimal, and the effectiveness of the drug is maximal. Tips for using a spray for the nose:
- Directly before using the spray, you need to clean the nasal cavity with saline.
- Suspension should be shaken and make the first injection into the air.
- Next, you need to lean slightly forward, inject the nebulizer into the nasal passage, pointing towards the outer wall of the cavity, and press the adapter. The described action is repeated for another nostril.
- After using the preparation, the spray nozzle needs to be wiped with a tissue and put the cap back in place.
- The bottle is stored vertically, periodically cleaning the nebulizer, which can become clogged. To do this, it is washed in warm water and dried.
Special instructions
During treatment, Tafen Nazal needs to be careful because of the risk of developing adrenal insufficiency and other side effects. Spray treatment is especially carefully performed by patients who have recently undergone nose surgery. In addition, with caution, doctors prescribe the drug to people who have nose injuries. This is due to the property of the drug to slow down the process of tissue repair( wound healing), in connection with which there is a risk of opening bleeding.
The drug does not affect a person's ability to drive and does not impair the speed of psychomotor reactions. Because of the lack of clinical experience with the use of the spray, it is not prescribed for the management and therapy of attacks of allergic rhinitis in children younger than 6 years. If necessary, these small patients need to be shown to a doctor who will choose the appropriate effective drug.
Tafen Nazal during pregnancy
During the first trimester, the use of Tafen Nazal is not recommended, because during this period of pregnancy the baby's organs and systems are formed, and there is no reliable data on the effect of the active component of the drug on the fetus. In the second and third trimester, the use of a medicinal product is possible only if the benefit to the woman exceeds the possible risks for the child. In this case, the medication is used in the minimal dosage and under the supervision of a doctor.
Interaction with other
medications With the simultaneous use of drops with inducers of microsomal oxidation such as Rifampicin, Phenytoin or Phenobarbital, the effectiveness of budesonide is reduced. Estrogens, methandienone and ketoconazole, on the contrary, enhance the effect of this substance, and Itraconazole can stimulate an increase in the plasma concentration of budesonide. Tafen Nazal is able to strengthen the therapeutic effect of vasoconstrictive nasal drugs, so combining such a means is not advisable, so as not to cause side effects.
Side effects of
During the application of nasal drops in patients, negative effects can occur, due, as a rule, to individual sensitivity to the components of the drug. These include:
- inflammation of the mucous membranes;
- nasal breathing disorder;
- cough;
- sneezing;
- a sore throat;
- dryness of the nasal mucosa;
- epistaxis;
- kidney failure;
- dizziness;
- drowsiness;
- growth retardation;
- perforation of the nasal septum;
- apathy, pr
Overdose
To avoid negative consequences, the dosage should be strictly observed. Cases of acute overdose have not been reported, but the drug is able to cause symptoms of hypercortisosis and other side effects described above. It is extremely rare, patients who have exceeded the dose have visual problems, glaucoma, cataracts become worse. In very large amounts, nasal drops can cause constriction of the bronchial lumen. Specific therapy of such conditions does not exist, therefore, supportive symptomatic drugs are used.
Conditions of sale and storage
The drug is dispensed in pharmacies according to the doctor's prescription. Keep the bottle in a cool, dark and dry place, protected from children. The expiration date at which budesonide remains active is 36 months from the date of manufacture. After this time, the spray for the nose is prohibited.
Analogues
Not only Tafen Nazal has an anti-inflammatory effect and reduces the severity of symptoms of rhinitis, sinusitis and other diseases of the upper respiratory tract. Structural analogues of the drug are:
- Budenofalk;
- Pulmicort;
- Benacourt;
- Budiere;
- Apulein;
- Benarin;
- Tafen.
Price Tafen Nazal
Budesonide reduces the inflammatory process, which leads to edema, decreases the secretion of mucus and the nose breathes. This therapeutic effect occurs soon after the application of Tafen Nazal, which causes its popularity in the treatment of rhinitis, polyps, sinusitis and other pathologies of the nose. The average price of the drug for pharmacies in Russia is 300-400 rubles.
Reviews
Alina, 31 year
Every spring I suffer from allergic rhinitis, which causes pollen of flowering plants. For a long time I use Tafen Nazal to eliminate unpleasant symptoms, while using the minimum daily dosage( 200 mcg).The two main advantages of the drug are its relatively low price and the rapid therapeutic effect.
Stanislav, 27 years old
After the appearance of severe itching and difficulty breathing turned to the otolaryngologist. The doctor prescribed a spray and promised that in a few days the symptoms would disappear. Reviews for Tafen Nazal are all entirely positive, so I without a doubt bought the drug, but its effect did not impress me: the symptoms disappear, but after the treatment is over, they return.
Pauline, 22 years old
After the injury, the septa of the nose are slightly curved, which makes breathing insignificant. In addition, every spring I suffer from allergies, which is manifested by constant sneezing, throat swelling, etc. Recently, on the recommendation of a doctor, Tafen Nazal discovered herself. Spray for the nose is very helpful, eliminating symptoms for 2-3 days.