Dienogest is a combination drug, which includes estrogen and progestogen. These are steroid sex hormones produced by the yellow body of the ovaries in women. Excess of estrogen in the body makes a woman bright, active, with a violent temperament, and the deficit, on the contrary, seems to extinguish female beauty and activity. Dienogest replenishes the number of female sex hormones during menopause.
- Composition and active ingredients
- Pharmacological properties
- Indications
- methods of administration and dosage
- Pregnancy
- Side effects
- Overdose symptoms
- Contraindications
- interaction with other drugs
- Analogs
- Visan
- Bonade
- Janine
- Klayra
- Dietsiklen
- Klimodien
- Storage conditions
Synthetic hormone is a derivative of nortestosterone, which is characterized by anti-androgenconstant activity. Dienogest has a high biological activity, due to which, it affects the progesterone receptors.
Composition and active ingredients
Tablet contains:
- Active ingredients - dienogest 2,000 milligrams.
- Additional substances - lactose monohydrate 62, 800 milligrams, cellulose 18, 000 milligrams, magnesium stearate 1.350 milligrams, potato starch 36,000 milligrams, talcum - 4,050 milligrams, crospovidone 2,700 milligrams.
Available in round, white or other color tablets with a flat surface.
Pharmacological properties
Dienogest is a drug characterized by antiandrogenic activity. Derivative of northeterone substance, getting into the uterus, binds to progesterone receptors. Despite the fact that dienogest is only 10% similar to progesterone, it has a strong effect.
In the treatment of endometriosis, the drug acts as follows: by suppressing the trophic effects of estrogens against the ectopic and eutopic endometrium, the formation of estrogens in the ovaries significantly decreases and their content in the patient's serum decreases.
With prolonged use of the drug in patients, decidualization of endometrial tissue with subsequent atrophy of the foci of endometriosis is observed. When you take the dienogest inside, the drug is easily and completely absorbed, the maximum concentration in the plasma is achieved after 2 hours. The drug is excreted from the patient's body in the form of metabolites, through the intestines and kidneys.
to contents ^Indications for use
It is used in the treatment of adenomyosis and endometriosis( inflammation of the uterus - endometrium).Used as hormone replacement therapy in women during menopause. Has contraceptive effect in combination with estrogens and can be used as a contraceptive.
to contents ^Methods of administration and dose of
The drug is administered on an individual basis, depending on the degree of the disease. In the manual, you can note the general data on the reception of Dienogest:
- Take 30 minutes before eating without chewing.
- The treatment period is 6-7 months.
- The first tablet is applied on any day of the menstrual period.
- Reception does not stop on the days of menstruation.
- Maximum daily dosage: 2 tablets( in case of skipping).
- Dienogest is taken at the same time every day.
- Drink strictly according to the scheme provided on the package.
Dienogest should be taken continuously, regardless of bleeding from the vagina. Prior to the reception, you need to make sure that the patient is not pregnant and to exclude pregnancy, it is recommended to use contraceptive methods during taking the drug.
to table of contents ^Pregnancy application
In pregnancy, any treatment with Dienogestom is contraindicated and delayed until delivery. Since during the gestation of a child in the treatment of endometriosis is not necessary. During the period of feeding, the drug is taken with the permission of a gynecologist and pediatrician.
to table of contents ^Side effects of
- Sexual system: hot flushes, discharge from the vagina of smearing character. There is discomfort of the mammary glands( densities), pain in the pelvic region.
- Respiratory system: rarely patients experience shortness of breath.
- Urinary system: cystitis, infection of the urinary tract( infrequently).
- Skin: rarely dry skin, itching.
- Digestive system: nausea, sensation of bloating, infrequent diarrhea or constipation, inflammation of the gastrointestinal tract;
- Nervous system: headache, sleep disturbance, mood swings.
Symptoms of overdose
Serious cases of overdose have not been fixed. Possible symptoms of drug overdose: vomiting, nausea, smearing discharge from the vagina. When symptoms occur, symptomatic therapy is necessary. The drug has no antidote, which is aimed at reducing the effect of toxic agents on the human body. In case of overdose, consult your doctor.
to table of contents ^Contraindications
Dienogest as containing gestagens is strictly contraindicated:
- Patients suffering from cardiovascular diseases.
- Persons with diseases of atherosclerosis, venous thromboembolism.
- In case of liver disease.
- With diabetes.
- When suspected of breast cancer.
- If the patient has allergies to the drug components.
- For children and teenagers.
It is recommended to use Dienogest with caution:
- Women with a diagnosis of intrauterine pregnancy.
- With high blood pressure.
- Patients suffering from hyperlipidemia.
Interaction with other drugs
Due to the fact that the effect of the latter is amplified. It is possible to use combination therapy with anti-inflammatory drugs. In this case, the treatment should be under the supervision of a doctor.
Dienogest with caution combined with Primidone, Nevirapine, Barbiturates, Phenytoin.
to table of contents ^Analogues
Dienogest substitutes are listed below, medicines similar in indications to application and their action on the human body.
Byzanne
Used for the treatment of endometriosis.
to the table of contents ^Bonade
Contraceptive( prevention of unwanted pregnancy), tablets have a dienogest as an active substance.
to the table of contents ^Jeanine
Contraceptive tablets. The composition includes dienogest.
to contents ^Clayra
Contraceptive combination drug( estrogen + progestogen).Tablets, covered with a shell of different colors.
to contents ^Diecyclene
Dienogest and ethinyl estradiol are included in the preparation. They are used as a contraceptive, and also for mild to moderate seborrhea.
to the table of contents ^Klimodien
Light pink tablets containing dienogest in the amount of 2 milligrams. It is used for women with estrogen deficiency. HRT - hormone replacement therapy is performed after a complete examination.
to contents ^Storage conditions
Tablets are stored in a dry and cool place out of the reach of children. The temperature in the room should not be more than 25 degrees. Shelf life is 2 years from the date of its manufacture.